Document Detail


Teratogenic effects of anticonvulsants.
MedLine Citation:
PMID:  6781455     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of malformations in fetal mice exposed to phenytoin depends on drug dosage and the strain of mice. Animal research also suggests that most anticonvulsants are teratogenic in experimental animals when large doses are used, but the effect of valproate sodium on the fetus is poorly known. Cleft lip and palatal defects have been most extensively studied, but defects have also been noted in eyes, heart, and limb buds. Data from humans are less clearer than the animal data, but human maternal exposure to anticonvulsants may increase infant clefting by threefold to tenfold. If a woman at risk for childbearing is given anticonvulsants for the first time, carbamazepine may be given first. Before pregnancy, the true need for anticonvulsants should be reassessed, but abrupt discontinuation of anticonvulsants during pregnancy is not now recommended.
Authors:
G W Paulson; R B Paulson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  38     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-04-24     Completed Date:  1981-04-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  140-3     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / etiology*
Animals
Anticonvulsants / adverse effects*
Carbamazepine / adverse effects
Cleft Palate / chemically induced,  etiology
Eyelid Diseases / chemically induced
Female
Humans
Mice
Palate
Phenytoin / adverse effects
Pregnancy / drug effects
Pregnancy Complications / prevention & control
Valproic Acid / adverse effects
Chemical
Reg. No./Substance:
0/Anticonvulsants; 298-46-4/Carbamazepine; 57-41-0/Phenytoin; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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