| Teratogenesis of alcohol. | |
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MedLine Citation:
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PMID: 8129276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many studies describing the teratogenic effects of alcohol have been published since Fetal Alcohol Syndrome (FAS) was first identified in 1973. Specifically, it has been a widely documented that alcohol is a teratogen that causes brain, craniofacial, and limb abnormalities in children suffering from FAS. These children have also been shown to be at high risk for mental deficiencies. Teratogenicity has only been observed in offspring of mothers who consume large quantities of alcohol during pregnancy, while the effects of moderate drinking, though linked with adverse fetal alcohol effects in many reports, are not yet clear. Studies have also shown that teratogenic effects of paternal drinking on newborns. Estimates of prevalence at birth of FAS range from 1.9 to 0.33 per 1,000 births, depending on race, population, socioeconomic status, etc. New hypotheses on the biochemical basis of ethanol-induced birth defects have been recently proposed, contributing to the understanding of alcohol teratogenicity. The following review focuses on major recent findings in this field and describes the current situation regarding FAS. |
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Authors:
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A Spagnolo |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Annali dell'Istituto superiore di sanità Volume: 29 ISSN: 0021-2571 ISO Abbreviation: Ann. Ist. Super. Sanita Publication Date: 1993 |
Date Detail:
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Created Date: 1994-04-11 Completed Date: 1994-04-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7502520 Medline TA: Ann Ist Super Sanita Country: ITALY |
Other Details:
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Languages: eng Pagination: 89-96 Citation Subset: IM |
Affiliation:
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Laboratorio di Epidemiologia e Biostatistica, Instituto Superiore di Sanità, Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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epidemiology,
etiology Alcohol Drinking / epidemiology Alcoholism / epidemiology Animals Ethanol / adverse effects*, toxicity Fathers Female Fetal Alcohol Syndrome / epidemiology, etiology*, physiopathology Humans Incidence Infant, Newborn Pregnancy Pregnancy Complications / epidemiology Prevalence |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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