| Teratogen-induced limb defects. | |
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MedLine Citation:
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PMID: 12357474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Limb abnormalities are one of the most common and visible phenotypic effects of several human teratogens. The specific effects are different for most teratogens and include effects on limb morphogenesis (thalidomide, warfarin, phenytoin, valproic acid) and the effect of vascular disruption on a limb that had formed normally (misoprostol, chorionic villus sampling, and phenytoin). Either duplication (preaxial polydactyly of hands and feet) or deficiency (absence of thumb) is a common effect of thalidomide; no other human teratogen identified to date has this effect on the developing limb. Procedures during pregnancy, including chorionic villus sampling and dilation and curettage, produce defects of vascular disruption. For common exposures, such as alcohol and cocaine, it has been difficult to confirm objectively the exposure during embryogenesis and to ascribe specific limb defects that are produced. The molecular basis for the limb defects produced by the recognized human teratogens remains unknown. |
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Authors:
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Lewis B Holmes |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of medical genetics Volume: 112 ISSN: 0148-7299 ISO Abbreviation: Am. J. Med. Genet. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-01 Completed Date: 2003-03-17 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7708900 Medline TA: Am J Med Genet Country: United States |
Other Details:
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Languages: eng Pagination: 297-303 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Wiley-Liss, Inc. |
Affiliation:
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Genetics and Teratology Unit, Pediatric Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. holmes.lewis@mgh.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chorionic Villi Sampling
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adverse effects Female Humans Limb Deformities, Congenital / chemically induced*, etiology, genetics Male Misoprostol / adverse effects Phenytoin / adverse effects Pregnancy Pregnancy in Diabetics Substance-Related Disorders / complications Teratogens / toxicity* Thalidomide / adverse effects Valproic Acid / adverse effects Warfarin / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Teratogens; 50-35-1/Thalidomide; 57-41-0/Phenytoin; 59122-46-2/Misoprostol; 81-81-2/Warfarin; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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