| Tepid antegrade and retrograde cardioplegia. | |
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MedLine Citation:
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PMID: 7887719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine the optimal temperature for the combination of antegrade and retrograde cardioplegia, 42 patients undergoing coronary artery bypass grafting were randomized to receive cold (9 degrees C; n = 14), tepid (29 degrees C; n = 14), or warm (37 degrees C; n = 14) blood cardioplegia delivered continuously retrograde and intermittently antegrade. Myocardial oxygen utilization, lactate and acid metabolism, and coronary vascular resistance were measured during the operation and cardiac function was assessed postoperatively. Myocardial oxygen consumption, lactate release and acid release were greatest with warm, intermediate with tepid, and least with cold cardioplegia (p = 0.0001). However, washout of lactate and acid at the time of cross-clamp release was reduced (p = 0.022) with tepid or cold compared with warm cardioplegia. Early postoperative left ventricular function was best preserved (p = 0.01) after tepid than after cold or warm combination cardioplegia. These results suggest that tepid combination cardioplegia reduced metabolic demands but permitted immediate recovery of cardiac function. This technique may provide better myocardial protection than cold or warm combination cardioplegia. |
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Authors:
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N Hayashida; R D Weisel; T Shirai; J S Ikonomidis; J Ivanov; S M Carson; M K Mohabeer; L C Tumiati; D A Mickle |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 59 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-04-07 Completed Date: 1995-04-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 723-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Biochemistry, Toronto Hospital, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Blood Flow Velocity Blood Pressure Coronary Artery Bypass / methods* Coronary Circulation Coronary Disease / metabolism, physiopathology, surgery* Female Heart Arrest, Induced / methods* Heart Rate Humans Intraoperative Care Lactates / metabolism Lactic Acid Male Middle Aged Oxygen Consumption Postoperative Care Temperature* Vascular Resistance Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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