Document Detail

Tenting area reflects disease severity and prognosis in patients with non-ischaemic dilated cardiomyopathy and functional mitral regurgitation.
MedLine Citation:
PMID:  21106544     Owner:  NLM     Status:  In-Data-Review    
AIMS: To define which echocardiographic parameters are related to the degree of functional mitral regurgitation (FMR) and to establish their relationship with clinical status, plasma B-type natriuretic peptide (BNP) levels, and prognosis in patients with non-ischaemic dilated cardiomyopathy (NICMP).
METHODS AND RESULTS: Ninety patients (mean age: 50 ± 14, 31% females) with NICMP and FMR were prospectively analysed by echocardiography. Global and local left ventricular remodelling parameters such as ejection fraction and sphericity index, inter-papillary muscle distance, coaptation to septal distance, and mitral annular area, as well as mitral valve deformation indices such as tenting area (TA) and tenting distance, were measured as indicators of FMR. Patients were defined as having severe FMR [effective regurgitant orifice area (EROA) ≥ 0.2 cm(2), n = 41] or non-severe FMR (EROA < 0.2 cm(2), n = 49) and followed for 15 ± 3 months. Multivariate regression analysis revealed that TA had the greatest ability to predict severe FMR at a cut-off level of 3.4 cm(2) with 82% sensitivity and 77% specificity. Patients with higher TA values (>3.4 cm(2)) had statistically higher BNP levels, worse functional status, more hospitalizations, and higher death rates. The plasma BNP level (P: 0.012) and TA (P: 0.056) were predictors of all-cause mortality. New York Heart Association class (P < 0.001) and TA (P: 0.005) were predictors of combined death or hospitalization on multivariate Cox's regression analysis.
CONCLUSION: Tenting area accurately reflects the degree of FMR at a cut-off value of 3.4 cm(2) and has a strong correlation with functional status, plasma BNP, mortality, and hospitalization rates. Tenting area is also an independent predictor of mortality and hospitalizations in patients with NICMP and FMR.
Oguz Karaca; Anil Avci; Gamze B Guler; Elnur Alizade; Ekrem Guler; Cetin Gecmen; Yunus Emiroglu; Ozlem Esen; Ali M Esen
Related Documents :
7443214 - Tear histamine levels in vernal conjunctivitis and other ocular inflammations.
8765104 - Acetaminophen and salicylate serum levels in patients with suicidal ingestion or altere...
21198274 - Elevated renin levels in patients with liver cirrhosis and hepatocellular carcinoma.
17725414 - No observable correlation between central nervous system side effects and efv plasma co...
10410784 - The case for neural tissue transplantation as a treatment for parkinson's disease.
23439574 - Functional and effective connectivity in eeg alpha and beta bands during intermittent f...
Publication Detail:
Type:  Journal Article     Date:  2010-11-23
Journal Detail:
Title:  European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology     Volume:  13     ISSN:  1879-0844     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  284-91     Citation Subset:  IM    
Cardiology Clinic, Kartal Kosuyolu Heart and Research Hospital, Istanbul, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Redistribution of left ventricular strain by cardiac resynchronization therapy in heart failure pati...
Next Document:  Immunohistochemical assessment for Cdx2 expression in the Barrett metaplasia-dysplasia-adenocarcinom...