Document Detail


Tension-free primary closure with autologous platelet gel versus Vivostat- for the definitive treatment of chronic sacrococcygeal pilonidal disease.
MedLine Citation:
PMID:  20668329     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: A randomized clinical trial was performed in patients with chronic or recurrent pilonidal sinus (PS) comparing primary closure coupled with random application of in house autologous platelet gel or produced by means of Vivostat- in order to assess whether a standardized product had an impact on the wound healing process. PATIENTS AND METHODS: Between June 2006 and June 2009, 100 patients (82 males, 18 females: median age 30 years; range, 16-51 years) underwent wide excision of the pilonidal area with midline tension-free closure and were randomly given either the in house autologous platelet gel (Group 1) or the Vivostat- gel (Group 2). RESULTS: Group 2 patients had shorter wound healing time (8 vs. 10 days; p<0.0001), time to return to full activity (11 vs. 16 days: p<0.0001), less uncomplicated fluid collections (120 vs. 190 ml: p<0.0001), and fewer postoperative wound complications (1/50=2% vs. 5/50=10%, p<0.001). After a median follow-up of 21 months (range: 4-40 months), two recurrences were detected in Group 1. CONCLUSION: The standardized production of platelet gel by means of the Vivostat- system guarantees the reproducibility of the procedure and its use was correlated with an improved outcome, with a high degree of patient satisfaction and better cosmetic results.
Authors:
Marco Gipponi; Giuliano Reboa; Tommaso Testa; Gabriella Giannini; Paolo Strada
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  24     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-07-29     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  583-9     Citation Subset:  IM    
Affiliation:
U.O.C. Chirurgia Generale, Colon-Retto-Ano, Azienda Ospedaliera Universitaria San Martino Genova, L.go R. Benzi, 10, 16132 Genoa, Italy. marco.gipponi@unige.it
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / surgery
Adolescent
Adult
Chronic Disease
Drainage / methods
Female
Gels / therapeutic use*
Humans
Male
Middle Aged
Pilonidal Sinus / surgery*
Platelet Transfusion / methods
Postoperative Complications / epidemiology
Recurrence
Surgical Flaps*
Surgical Wound Dehiscence
Transplantation, Autologous
Wound Healing
Chemical
Reg. No./Substance:
0/Gels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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