Document Detail

Tensile load and the metabolism of anterior cruciate ligament cells.
MedLine Citation:
PMID:  9728181     Owner:  NLM     Status:  MEDLINE    
It generally is recognized that tensile load plays a major role in maintaining the homeostasis of the anterior cruciate ligament fibers, but its detailed mechanism remains a matter of controversy. The effect of cyclic tensile load on the metabolism of the anterior cruciate ligament were investigated experimentally using cultured cells from the anterior cruciate ligament of rabbits. Using culture plates with flexible rubber bases, a cyclic tensile load was applied to the cultured cells for 24 hours, and the changes in shape, alignment, and metabolism of the cells were analyzed. Under the cyclic tensile load, the shape of the cells from the anterior cruciate ligament changed to spindle and aligned perpendicularly to the direction of the tensile load. The cyclic tensile load also caused an increase in collagen synthesis by the cells from the anterior cruciate ligament, which was predominant in Type I. The cells from the synovium showed similar changes in shape and alignment under the cyclic tensile load, but no significant change was observed in cell metabolism. These observations suggest that the application of cyclic tensile load on the anterior cruciate ligament cells is an important factor in the regulation of collagen synthesis in the anterior cruciate ligament.
T Toyoda; H Matsumoto; K Fujikawa; S Saito; K Inoue
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  -     ISSN:  0009-921X     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-09-17     Completed Date:  1998-09-17     Revised Date:  2005-03-03    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  247-55     Citation Subset:  AIM; IM; S    
Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan.
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MeSH Terms
Anterior Cruciate Ligament / cytology*,  metabolism,  physiology
Cell Cycle
Cell Size
Cells, Cultured
Collagen / biosynthesis
DNA / biosynthesis
Synovial Membrane / cytology
Tensile Strength
Reg. No./Substance:
9007-34-5/Collagen; 9007-49-2/DNA

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