| Tensile load and the metabolism of anterior cruciate ligament cells. | |
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MedLine Citation:
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PMID: 9728181 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It generally is recognized that tensile load plays a major role in maintaining the homeostasis of the anterior cruciate ligament fibers, but its detailed mechanism remains a matter of controversy. The effect of cyclic tensile load on the metabolism of the anterior cruciate ligament were investigated experimentally using cultured cells from the anterior cruciate ligament of rabbits. Using culture plates with flexible rubber bases, a cyclic tensile load was applied to the cultured cells for 24 hours, and the changes in shape, alignment, and metabolism of the cells were analyzed. Under the cyclic tensile load, the shape of the cells from the anterior cruciate ligament changed to spindle and aligned perpendicularly to the direction of the tensile load. The cyclic tensile load also caused an increase in collagen synthesis by the cells from the anterior cruciate ligament, which was predominant in Type I. The cells from the synovium showed similar changes in shape and alignment under the cyclic tensile load, but no significant change was observed in cell metabolism. These observations suggest that the application of cyclic tensile load on the anterior cruciate ligament cells is an important factor in the regulation of collagen synthesis in the anterior cruciate ligament. |
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Authors:
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T Toyoda; H Matsumoto; K Fujikawa; S Saito; K Inoue |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical orthopaedics and related research Volume: - ISSN: 0009-921X ISO Abbreviation: Clin. Orthop. Relat. Res. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-09-17 Completed Date: 1998-09-17 Revised Date: 2005-03-03 |
Medline Journal Info:
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Nlm Unique ID: 0075674 Medline TA: Clin Orthop Relat Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 247-55 Citation Subset: AIM; IM; S |
Affiliation:
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Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anterior Cruciate Ligament / cytology*, metabolism, physiology Cell Cycle Cell Size Cells, Cultured Collagen / biosynthesis DNA / biosynthesis Rabbits Synovial Membrane / cytology Tensile Strength |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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