Document Detail

Tensegrin in context: Dual role of α8 integrin in the migration of different cell types.
MedLine Citation:
PMID:  20543583     Owner:  NLM     Status:  MEDLINE    
α8β1 integrin is highly expressed in cells with contractile function, such as mesangial cells of the kidneys and vascular smooth muscle cells (VSMCs). Although it promotes migration of neural crest cells and breast cancer cells, recent studies suggest that α8 integrin has a negative regulatory role in VSMC migration. In this review, the question of why α8β1 integrin plays a dual role in cell migration is raised and discussed. It seems that cells require optimum contractility and balanced tensile forces for migration. α8β1 integrin promotes migration of cells that are initially in a less than optimal contractile state (e.g. neural cells) and reduces the migration of cells known as contractile cells. α8β1 integrin can be called “Tensegrin” as it fits perfectly into the tensegrity model (tensional integrity) and seems to play a prominent role in the integration of the tensile forces.
Ramin Zargham
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cell adhesion & migration     Volume:  4     ISSN:  1933-6926     ISO Abbreviation:  Cell Adh Migr     Publication Date:    2010 Oct-Dec
Date Detail:
Created Date:  2011-04-18     Completed Date:  2011-06-21     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101469464     Medline TA:  Cell Adh Migr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  485-90     Citation Subset:  IM    
McGill University, Experimental Medicine Department, Montreal, QC, Canada.
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MeSH Terms
Antigens, Differentiation / physiology*
Cell Movement*
Cell Proliferation
Integrins / physiology*
Muscle Contraction
Muscle, Smooth, Vascular / cytology*,  physiology
Stress, Mechanical
Reg. No./Substance:
0/Antigens, Differentiation; 0/Integrins; 0/integrin alpha8beta1

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