| Tenofovir useand pregnancy among women initiating HAART. | |
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MedLine Citation:
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PMID: 22951630 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE:: Recent studies have raised concerns about a change in rates of pregnancy among HIV-negative women exposed to tenofovir.Here, our objective was todetermine among HIV-positive women whether use of tenofovir at HAART initiation or thereafter is associated with subsequent changes in incidence of pregnancy. DESIGN:: Analysis of prospectively collected clinical data. METHODS:: We used Cox proportional hazards models and logistic regression to estimate hazard ratios and odds-ratios for the association of baseline tenofovir use and time to first incident pregnancy. We used marginal structural Cox models to estimate hazard ratios for the association of current tenofovir use and time to first incident pregnancy. RESULTS:: We studied 7,275 women, of whom 1,199 were initiated on tenofovir-based HAART regimens, and who experienced a total of 894 pregnancies in 17,200 person-years of follow-up. Analyses showed slight reductions in hazards of pregnancy among women who used tenofovir, but without sufficient precision to draw strong conclusions. Sensitivity analyses confirmed main results. CONCLUSIONS:: Tenofovir may be associated with a lower hazard or rate of pregnancy in women receiving HAART. However, conclusions are limited by low precision, the observational nature of the data, and possible uncontrolled confounding by temporal trends in contraception use and other factors. |
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Authors:
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Mhairi Maskew; Daniel Westreich; Cindy Firnhaber; Ian Sanne |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-28 |
Journal Detail:
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Title: AIDS (London, England) Volume: - ISSN: 1473-5571 ISO Abbreviation: AIDS Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-9-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710219 Medline TA: AIDS Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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aHealth Economics and Epidemiology Research Office, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa bDepartment of Obstetrics and Gynecology and Duke Global Health Institute, Duke University, Durham NC cClinical HIV Research Unit, Department of Medicine, Faculty of Health Sciences, University of the Witwatersrand, South Africa dRight to Care, Johannesburg, South Africa. |
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