Document Detail


Tenofovir-related nephrotoxicity: case report and review of the literature.
MedLine Citation:
PMID:  15040657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tenofovir is a nucleotide reverse transcriptase inhibitor for treatment of human immunodeficiency virus (HIV) infection. Several cases of renal failure associated with tenofovir therapy recently have been reported. A 54-year-old man with HIV experienced decreasing renal function and Fanconi's syndrome secondary to tenofovir therapy. His condition gradually improved after discontinuation of the drug. The available medical literature for reported cases of tenofovir-related nephrotoxicity indicates that this complication is apparently rare. However, our case report and literature review underscore the importance of monitoring renal function when treating patients with any nucleotide reverse transcriptase inhibitor.
Authors:
Christopher W James; Mary C Steinhaus; Susan Szabo; Robert M Dressier
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Pharmacotherapy     Volume:  24     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-25     Completed Date:  2004-08-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  415-8     Citation Subset:  IM    
Affiliation:
HIV Community Program, Christiana Care Health Services, Wilmington, Delaware 19899-1668, USA. Cjames@christianacare.org
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MeSH Terms
Descriptor/Qualifier:
Acquired Immunodeficiency Syndrome / complications,  diagnosis,  drug therapy
Adenine / adverse effects*,  analogs & derivatives*,  therapeutic use
Anti-HIV Agents / therapeutic use
Clinical Chemistry Tests / methods
Fanconi Syndrome / chemically induced,  complications,  diagnosis
Female
Humans
Kidney Failure, Acute / chemically induced*,  complications,  diagnosis
Male
Middle Aged
Organophosphorus Compounds / adverse effects*,  therapeutic use
Phosphonic Acids*
Reverse Transcriptase Inhibitors / adverse effects,  therapeutic use
Stavudine / therapeutic use
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/Organophosphorus Compounds; 0/Phosphonic Acids; 0/Reverse Transcriptase Inhibitors; 107021-12-5/tenofovir; 3056-17-5/Stavudine; 73-24-5/Adenine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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