| Tenofovir-related nephrotoxicity: case report and review of the literature. | |
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MedLine Citation:
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PMID: 15040657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tenofovir is a nucleotide reverse transcriptase inhibitor for treatment of human immunodeficiency virus (HIV) infection. Several cases of renal failure associated with tenofovir therapy recently have been reported. A 54-year-old man with HIV experienced decreasing renal function and Fanconi's syndrome secondary to tenofovir therapy. His condition gradually improved after discontinuation of the drug. The available medical literature for reported cases of tenofovir-related nephrotoxicity indicates that this complication is apparently rare. However, our case report and literature review underscore the importance of monitoring renal function when treating patients with any nucleotide reverse transcriptase inhibitor. |
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Authors:
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Christopher W James; Mary C Steinhaus; Susan Szabo; Robert M Dressier |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Pharmacotherapy Volume: 24 ISSN: 0277-0008 ISO Abbreviation: Pharmacotherapy Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-25 Completed Date: 2004-08-19 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8111305 Medline TA: Pharmacotherapy Country: United States |
Other Details:
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Languages: eng Pagination: 415-8 Citation Subset: IM |
Affiliation:
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HIV Community Program, Christiana Care Health Services, Wilmington, Delaware 19899-1668, USA. Cjames@christianacare.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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complications,
diagnosis,
drug therapy Adenine / adverse effects*, analogs & derivatives*, therapeutic use Anti-HIV Agents / therapeutic use Clinical Chemistry Tests / methods Fanconi Syndrome / chemically induced, complications, diagnosis Female Humans Kidney Failure, Acute / chemically induced*, complications, diagnosis Male Middle Aged Organophosphorus Compounds / adverse effects*, therapeutic use Phosphonic Acids* Reverse Transcriptase Inhibitors / adverse effects, therapeutic use Stavudine / therapeutic use Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Organophosphorus Compounds; 0/Phosphonic Acids; 0/Reverse Transcriptase Inhibitors; 107021-12-5/tenofovir; 3056-17-5/Stavudine; 73-24-5/Adenine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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