| Tenofovir-linked hyperparathyroidism is independently associated with the presence of vitamin D deficiency. | |
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MedLine Citation:
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PMID: 20672448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To determine patient and treatment characteristics associated with vitamin D deficiency (VDD) in an UK inner city HIV-1-positive adult cohort. METHODS: Two hundred twenty-seven HIV-positive patients attending prospectively for routine blood tests in winter had serum 25-hydroxyvitamin D and parathyroid hormone (PTH) concentrations and other routine chemistry measured. Those with and without VDD were defined as having serum 25-hydroxyvitamin D concentrations <50 nmol/L and >75 nmol/L, respectively. Characteristics were compared between patients with and without VDD. The effects of VDD, tenofovir use, and their interaction on chemical measures were investigated. RESULTS: VDD was found in 57% (131 of 227) of patients. Independent associations included nonwhite ethnicity [adjusted odds ratio (95% confidence interval): 7.40 (2.52 to 21.7)], higher random blood glucose [2.38 (1.24 to 4.57) per mmol/L], higher estimated glomerular filtration rate [eGFR: 1.04 (1.01 to 1.06)], and higher PTH [1.19 (1.00 to 1.42)]. PTH was higher in those receiving tenofovir (median 7.2 pmol/L) than other patients (4.3; P < 0.001) overall, but high PTH with tenofovir occurred only in the context of VDD. Tenofovir use was not associated with serum creatinine or eGFR overall but interacted with vitamin D status (P = 0.05 and P = 0.08, respectively), being linked to somewhat higher creatinine and lower eGFR among patients without VDD but higher eGFR in VDD patients. CONCLUSIONS: 25(OH) VDD is associated with tenofovir-linked hyperparathyroidism and also with higher eGFR. |
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Authors:
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Melanie M Rosenvinge; Keertie Gedela; Andrew J Copas; Anne Wilkinson; Catriona A Sheehy; Gul Bano; Phillip E Hay; Mark R Pakianathan; S Tariq Sadiq |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of acquired immune deficiency syndromes (1999) Volume: 54 ISSN: 1944-7884 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-29 Completed Date: 2010-08-12 Revised Date: 2011-09-06 |
Medline Journal Info:
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Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: United States |
Other Details:
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Languages: eng Pagination: 496-9 Citation Subset: IM; X |
Affiliation:
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Department of Genitourinary Medicine, St. George's Healthcare NHS Trust, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenine
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adverse effects,
analogs & derivatives*,
therapeutic use Adult Female Great Britain HIV Infections / complications*, drug therapy*, virology HIV-1 / isolation & purification Humans Hyperparathyroidism / chemically induced* Male Middle Aged Parathyroid Hormone / blood Phosphonic Acids / adverse effects*, therapeutic use* Urban Population Vitamin D / analogs & derivatives, blood Vitamin D Deficiency / complications* |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone; 0/Phosphonic Acids; 107021-12-5/tenofovir; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D; 73-24-5/Adenine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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