| Tenecteplase and return of spontaneous circulation after refractory cardiopulmonary arrest. | |
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MedLine Citation:
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PMID: 15558935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Even with the benefit of cardiopulmonary resuscitation, the prognosis of cardiac arrest remains poor. Multiple case series describe survival with the use of thrombolytic therapy for refractory cardiac arrest. Presumably thrombolysis treats that subset of cardiac arrest cases resulting from fulminant pulmonary embolism, or perhaps massive myocardial infarctions. Published reports to date have dealt exclusively with streptokinase, urokinase, reteplase, or recombinant tissue plasminogen activator. The authors report the first case of return of spontaneous circulation with the administration of tenecteplase. Tenecteplase is a recently developed reengineered isomer of tissue plasminogen activator that possesses many properties of the ideal cardiac arrest thrombolytic agent. It is bolus dosed, stable at room temperature before reconstitution, and is compatible with most other advanced cardiac life support medications. Because of clinical equivalency and its logistical advantages, tenecteplase should be evaluated as an alternative to other thrombolytics in future trials involving cardiac arrest. |
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Authors:
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Bruce D Adams; James Y Kim; Walter O Jackson |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Southern medical journal Volume: 97 ISSN: 0038-4348 ISO Abbreviation: South. Med. J. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-11-22 Completed Date: 2004-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404522 Medline TA: South Med J Country: United States |
Other Details:
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Languages: eng Pagination: 1015-7 Citation Subset: AIM; IM |
Affiliation:
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US Army, Department of Emergency Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas 78234, USA. bruce.adams@amedd.army.mil |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Circulation / drug effects Fatal Outcome Fibrinolytic Agents / therapeutic use* Heart Arrest / drug therapy* Humans Male Postoperative Complications Pulmonary Embolism / drug therapy Tissue Plasminogen Activator / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 0/tenecteplase; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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