Document Detail


Tendon-derived stem cells as a new cell source for tendon tissue engineering.
MedLine Citation:
PMID:  23276960     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tendon injuries are very common in occupational and athletic settings, and the elderly population. Tendons repair and regenerate slowly and inefficiently in vivo after injury. The limited ability of tendons to self-repair and the general inefficiency of current treatment strategies have intensified the need for an effective therapeutic approach. Tendon-derived stem cells (TDSCs) have recently been identified within tendon tissues. TDSCs exhibit universal stem cell characteristics, such as clonogenicity, a high proliferative capacity, multi-differentiation potential, non-immunogenicity, and immunosuppression. As a result, implanting TDSCs at damaged sites within tendons may be an effective way for tendon regeneration. This review summarizes the properties of TDSCs and discusses the advantages of its use in tendon tissue engineering.
Authors:
Qiang Zhang; Biao Cheng
Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Landmark edition)     Volume:  18     ISSN:  1093-4715     ISO Abbreviation:  Front Biosci (Landmark Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-12     Revised Date:  2013-07-29    
Medline Journal Info:
Nlm Unique ID:  101612996     Medline TA:  Front Biosci (Landmark Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  756-64     Citation Subset:  IM    
Affiliation:
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Yanchang Middle Road, Shanghai 200072, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Animals
Biomechanics
Cell Differentiation
Cell Proliferation
Cells, Cultured
Extracellular Matrix Proteins / metabolism
Humans
Regeneration
Stem Cell Transplantation*
Stem Cells / cytology*
Tendon Injuries / therapy*
Tendons / cytology*,  metabolism
Tissue Engineering
Chemical
Reg. No./Substance:
0/Extracellular Matrix Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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