| Tendency to angry rumination predicts stress-provoked endothelin-1 increase in patients with coronary artery disease. | |
| | |
MedLine Citation:
|
PMID: 20368479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine whether a tendency to angry rumination predicts anger recall (AR) stress-provoked increase in endothelin (ET)-1 among patients with coronary heart disease (CHD). METHODS: Patients with chronic stable CHD (n = 105) completed a five-item measure of tendency to angry rumination (DAB-VR) and underwent a laboratory AR stress protocol (15-minute resting baseline [BL], 8-minute AR). Blood samples drawn at end of BL and AR were assayed for ET-1. Change in ET-1 from BL to AR (increase versus decrease/no change) was treated dichotomously in multivariate logistic regression models, including DAB-VR score and potential confounders, to evaluate the contribution of DAB-VR to the prediction of change in ET-1. RESULTS: In the multivariate model, DAB-VR score significantly predicted ET-1 increase (odds ratio, 1.34; 95% confidence interval, 1.10-1.1.63; p = .004), controlling for age, history of diabetes, hypercholesterolemia, rate pressure product, use of beta blockers, and statins. CONCLUSIONS: A tendency to angry rumination independently predicted AR stress-provoked ET-1 increase among patients with CHD. Given the involvement of ET-1 in plaque rupture, anger rumination tendency may identify vulnerability to anger-triggered acute coronary syndrome through prolongation of initial anger mobilization. The contribution of ruminative thinking to sustained poststress ET-1 elevation and the synergistic relationship of ET-1 during emotional stress with norepinephrine and nitric oxide remain to be explored. |
| | |
Authors:
|
Antonio B Fernandez; Robert Soufer; Dorothea Collins; Aaron Soufer; Hooman Ranjbaran; Matthew M Burg |
Related Documents
:
|
15732229 - Sonovue improves endocardial border detection and variability in assessing wall motion ... 10147729 - Echocardiography in coronary artery disease. 17309909 - Safety and diagnostic accuracy of stress cardiac magnetic resonance imaging vs exercise... 17336749 - Risk stratification using stress echocardiography: incremental prognostic value over hi... 7375629 - Attributed responsibility for life events in survivors of myocardial infarction. 10590829 - Intrusive memories, post-traumatic stress disorder and myocardial infarction. 10978989 - Identification of viable myocardium by perfusion imaging with intravenous contrast echo... 22019599 - Impact of heart rate and rhythm on radiation exposure in prospectively ecg triggered co... 18418309 - Safety and efficacy of drug-eluting stents: on-label and off-label perspectives. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-04-05 |
Journal Detail:
|
Title: Psychosomatic medicine Volume: 72 ISSN: 1534-7796 ISO Abbreviation: Psychosom Med Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-05-11 Completed Date: 2010-07-15 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 0376505 Medline TA: Psychosom Med Country: United States |
Other Details:
|
Languages: eng Pagination: 348-53 Citation Subset: IM |
Affiliation:
|
Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Anger / physiology* Coronary Disease / blood*, diagnosis Data Collection / statistics & numerical data Electrocardiography Endothelin-1 / blood* Female Health Status Humans Male Mental Recall / physiology* Middle Aged Norepinephrine / blood Risk Assessment Risk Factors Stress, Psychological / blood* Thinking / physiology Ventricular Dysfunction, Left / blood, diagnosis |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HL059619-07/HL/NHLBI NIH HHS; R01 HL071116-01/HL/NHLBI NIH HHS; R01 HL071116-04/HL/NHLBI NIH HHS; R01 HL59619-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Endothelin-1; 51-41-2/Norepinephrine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Oxytocin Attenuates Atherosclerosis and Adipose Tissue Inflammation in Socially Isolated ApoE-/- Mic...
Next Document: Partner Violence and Psychological Well-Being: Buffer or Indirect Effect of Social Support.