Document Detail


Tendency to angry rumination predicts stress-provoked endothelin-1 increase in patients with coronary artery disease.
MedLine Citation:
PMID:  20368479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether a tendency to angry rumination predicts anger recall (AR) stress-provoked increase in endothelin (ET)-1 among patients with coronary heart disease (CHD).
METHODS: Patients with chronic stable CHD (n = 105) completed a five-item measure of tendency to angry rumination (DAB-VR) and underwent a laboratory AR stress protocol (15-minute resting baseline [BL], 8-minute AR). Blood samples drawn at end of BL and AR were assayed for ET-1. Change in ET-1 from BL to AR (increase versus decrease/no change) was treated dichotomously in multivariate logistic regression models, including DAB-VR score and potential confounders, to evaluate the contribution of DAB-VR to the prediction of change in ET-1.
RESULTS: In the multivariate model, DAB-VR score significantly predicted ET-1 increase (odds ratio, 1.34; 95% confidence interval, 1.10-1.1.63; p = .004), controlling for age, history of diabetes, hypercholesterolemia, rate pressure product, use of beta blockers, and statins.
CONCLUSIONS: A tendency to angry rumination independently predicted AR stress-provoked ET-1 increase among patients with CHD. Given the involvement of ET-1 in plaque rupture, anger rumination tendency may identify vulnerability to anger-triggered acute coronary syndrome through prolongation of initial anger mobilization. The contribution of ruminative thinking to sustained poststress ET-1 elevation and the synergistic relationship of ET-1 during emotional stress with norepinephrine and nitric oxide remain to be explored.
Authors:
Antonio B Fernandez; Robert Soufer; Dorothea Collins; Aaron Soufer; Hooman Ranjbaran; Matthew M Burg
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-04-05
Journal Detail:
Title:  Psychosomatic medicine     Volume:  72     ISSN:  1534-7796     ISO Abbreviation:  Psychosom Med     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-11     Completed Date:  2010-07-15     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  348-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Anger / physiology*
Coronary Disease / blood*,  diagnosis
Data Collection / statistics & numerical data
Electrocardiography
Endothelin-1 / blood*
Female
Health Status
Humans
Male
Mental Recall / physiology*
Middle Aged
Norepinephrine / blood
Risk Assessment
Risk Factors
Stress, Psychological / blood*
Thinking / physiology
Ventricular Dysfunction, Left / blood,  diagnosis
Grant Support
ID/Acronym/Agency:
R01 HL059619/HL/NHLBI NIH HHS; R01 HL059619-07/HL/NHLBI NIH HHS; R01 HL071116/HL/NHLBI NIH HHS; R01 HL071116-01/HL/NHLBI NIH HHS; R01 HL071116-04/HL/NHLBI NIH HHS; R01 HL59619-01/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Endothelin-1; X4W3ENH1CV/Norepinephrine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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