Document Detail


Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid.
MedLine Citation:
PMID:  9310019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tenascin and fibronectin are extracellular matrix glycoproteins expressed during morphogenesis and tissue repair. In the present study bronchial biopsies were studied by the morphometric method of immunocytochemistry to reveal the distribution of different tenascin and fibronectin isoforms as well as the presence of inflammatory cells in the airway mucosa of patients with chronic asthma (n = 32) and those with seasonal birch-pollen-sensitive asthma out of season (n = 17), both in comparison with healthy control subjects (n = 12). The results showed an increase in tenascin immunoreactivity in the bronchial subepithelial reticular basement membrane layer in patients with chronic asthma (p < 0.0001) and in those with seasonal asthma (p < 0.01) compared with control subjects. The tenascin immunoreactivity, appearing as an intense wide subepithelial band in asthma, was seen only occasionally in the basement membrane of control specimens. Instead, a diffuse immunoreaction against both total fibronectin and locally produced extradomain A fibronectin was similarly visible in the airway mucosa of both patients and control subjects. Despite the significant increase in the airway mucosa of eosinophils and lymphocytes in patients with chronic asthma (p < 0.0001 and p < 0.0001, respectively) and of eosinophils in patients with seasonal asthma (p < 0.001), there was no correlation between the number of these cell types and level of tenascin expression. In patients with birch-pollen-sensitive asthma during the birch-pollen season, inhaled corticosteroid treatment, budesonide 400 micrograms twice daily, decreased tenascin immunoreactivity, in comparison with effects of placebo (p = 0.01). Our results suggest that the higher amount of tenascin reflects disease activity in asthma and may be an indicator of a remodeling process rather than of injury itself.
Authors:
A Laitinen; A Altraja; M Kämpe; M Linden; I Virtanen; L A Laitinen
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  156     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-28     Completed Date:  1997-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  951-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Anatomy, University of Helsinki, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Inflammatory Agents / pharmacology*
Asthma / drug therapy,  immunology*,  pathology*
Basement Membrane
Biopsy
Bronchi / pathology*
Budesonide / pharmacology*
Case-Control Studies
Chronic Disease
Female
Fibronectins / analysis*,  drug effects
Humans
Immunohistochemistry
Male
Middle Aged
Seasons
Tenascin / analysis*,  drug effects
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Fibronectins; 0/Tenascin; 51333-22-3/Budesonide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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