Document Detail

Ten years of progress in the Hokkaido birth cohort study on environment and children's health: cohort profile--updated 2013.
MedLine Citation:
PMID:  23959649     Owner:  NLM     Status:  MEDLINE    
The Hokkaido Study on Environment and Children's Health is an ongoing cohort study that began in 2002. The study consists of two prospective birth cohorts, the Sapporo cohort (n = 514) and the Hokkaido large-scale cohort (n = 20,940). The primary goals of this study are to first examine the potential negative effects of perinatal environmental chemical exposures on birth outcomes, including congenital malformations and growth retardation; second, to evaluate the development of allergies, infectious diseases and neurodevelopmental disorders and perform longitudinal observations of the children's physical development to clarify the causal relationship between these outcomes and environmental chemicals; third, to identify individuals genetically susceptible to environmental chemicals; finally, to identify the additive effects of various environmental factors in our daily life, such as secondhand smoke exposure or low folate intake during early pregnancy. In this paper, we introduce our recent progress in the Hokkaido study with a cohort profile updated in 2013. For the last ten years, we followed pregnant women and their offspring, measuring various environmental chemicals, i.e., PCB, OH-PCB and dioxins, PFCs (Perfluorinated Compounds), Organochlorine pesticides, Phthalates, bisphenol A and mercury. We discovered that the concentration of toxic equivalents (TEQ) of dioxin and other specific congeners of PCDF or PCDD have effects on birth weight, infants' neurodevelopment and immune function. There were significant gender differences in these effects; our results suggest that male infants have more susceptibility to those chemical exposures than female infants. Interestingly, we found maternal genetic polymorphisms in AHR, CYP1A1 or GSTs that significantly modified the dioxin concentrations in maternal blood, suggesting different dioxin accumulations in the bodies of individuals with these genotypes, which would lead to different dioxin exposure levels. These genetic susceptibility factors influenced the body size of children born from mothers that either smoked or were passively exposed to tobacco smoke. Further studies investigating the correlation between epigenetics, the effects of intrauterine exposure to environmental chemicals and developmental factors related to health and disease are warranted.
Reiko Kishi; Sachiko Kobayashi; Tamiko Ikeno; Atsuko Araki; Chihiro Miyashita; Sachiko Itoh; Seiko Sasaki; Emiko Okada; Sumitaka Kobayashi; Ikuko Kashino; Kumiko Itoh; Sonomi Nakajima;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Environmental health and preventive medicine     Volume:  18     ISSN:  1347-4715     ISO Abbreviation:  Environ Health Prev Med     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-12-20     Completed Date:  2014-06-11     Revised Date:  2014-11-04    
Medline Journal Info:
Nlm Unique ID:  9609642     Medline TA:  Environ Health Prev Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  429-50     Citation Subset:  IM    
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MeSH Terms
Child Development / drug effects
Cohort Studies
Communicable Diseases / chemically induced,  epidemiology*,  genetics
Environmental Exposure*
Environmental Pollutants / toxicity*
Genetic Predisposition to Disease / epidemiology,  etiology
Hypersensitivity / epidemiology*,  etiology,  genetics
Japan / epidemiology
Longitudinal Studies
Nervous System Diseases / chemically induced,  epidemiology*,  genetics
Prospective Studies
Sex Factors
Reg. No./Substance:
0/Environmental Pollutants
S Tajima / ; H Goudarzi / ; K Azumi / ; A Kanazawa / ; Y Otake / ; T A Yila / ; Y Ait Bamai / ; S Cong / ; Tos Baba / ; T S Braimoh / ; S Ban / ; N Washino / ; K Konishi / ; S Kato / ; A Uno / ; M Limpar / ; H Minakami / ; K Nonomura / ; T Mitsui / ; T Endo / ; Tsu Baba / ; K Sengoku / ; Y Saijo / ; E Yoshioka / ; T Miyamoto / ; M Yuasa / ; F Sata / ; N Kurahashi / ; J Tamaki / ; J Kajiwara / ; T Todaka / ; H Murohashi / ; H Matsuura / ; T Matsumura / ; M Ishizuka /

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