| Ten years experience on needle biopsy in the early diagnosis of sacroiliitis. | |
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MedLine Citation:
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PMID: 22076932 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the significance of needle biopsy in the early diagnosis of sacroiliitis in order to improve the diagnostic level and outcome of ankylosing spondylitis. PATIENTS AND METHODS: One hundred nine patients highly suspected to have early ankylosing spondylitis, but with a radiograph/CT sacroiliitis < grade II, were recruited. CT-guided needle biopsy of sacroiliac joints was performed, and patients were followed for 5-10 years. RESULTS: Of the 109 cases, MRI was used in 77 cases to confirm the presence or absence of sacroiliitis. Of these, 23 cases were determined to have MRI sacroiliitis, and no MRI sacroiliitis in 54 cases. A needle biopsy was performed on all 109 patients. Inflammatory features were found in 85 cases, which included the 23 MRI sacroiliitis cases and the 38 no MRI sacroiliitis patients. No inflammatory features were found in 24 cases, including the remaining 16 cases without MRI sacroiliitis. Specificity and sensitivity of MRI for early diagnosis of sacroiliitis in these patients were 100% and 37.7% respectively. Thirty four cases with pathological sacroiliitis were followed up for 5-10 years. At endpoint, 16 cases remained in < grade II, and 18 revealed ≥ grade II CT sacroiliitis. Among the 18 ≥ grade II CT sacroiliitis cases, 7 were from the 8 cases diagnosed with MRI sacroiliitis, and 6 were from the 20 patients confirmed not to have MRI sacroiliitis at baseline. CONCLUSION: MRI, though of low sensitivity, is specific for the diagnosis of early sacroiliitis. Needle biopsy can detect sacroiliitis earlier than MRI. © 2011 American College of Rheumatology. |
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Authors:
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Yao Gong; Nan Zheng; Subiao Chen; Zhengyu Xiao; Mingyao Wu; Yuan Liu; Qingyu Zeng |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-10 |
Journal Detail:
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Title: Arthritis and rheumatism Volume: - ISSN: 1529-0131 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 by the American College of Rheumatology. |
Affiliation:
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Department of Rheumatology, the First Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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