Document Detail


Ten years' experience of antenatal mean corpuscular volume screening and prenatal diagnosis for thalassaemias in Hong Kong.
MedLine Citation:
PMID:  10932983     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the prevalence of thalassaemia carriers in Hong Kong. SUBJECTS AND METHODS: From 1988 to 1997, 25,834 (53.7%) of 48,089 mothers were screened for thalassaemias by mean corpuscular volume (MCV) at the first antenatal visit. RESULTS: In the screened population of 25,834, 2229 (8.6%) had MCV < or = 75 fl. Of these, 1121 (4.3%) were alpha-thal, 715 (2.8%) were beta-thal, 23 (0.1%) were alpha beta-thal, 57 (0.2%) were other haemoglobin variants, and 281 (1.1%) had either iron deficiency or uncertain causes. Out of 200 pregnancies at risk for homozygous alpha-thal-1 and 32 at risk for beta-thal major, 27 homozygous alpha-thal-1 and 7 beta-thal major were identified, compared favourably with the expected figures of 23 and 9. CONCLUSION: Antenatal screening for thalassaemias by MCV is simple, effective and reliable. Universal screening has a different impact as bone marrow or cord blood stem cell transplant provides cure for beta-thal major. At risk couples have, as an alternative to termination of pregnancy, the option of early detection and treatment for their affected newborns or fetuses.
Authors:
S Y Sin; A Ghosh; L C Tang; V Chan
Related Documents :
23810563 - Serum preadipocyte factor-1 is increased in fetuses of pregnancy complicated with sever...
23884273 - Baking soda pica associated with rhabdomyolysis and cardiomyopathy in pregnancy.
7003793 - The fetal alcohol syndrome in mice: maternal variables.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  26     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-17     Completed Date:  2000-08-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  203-8     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Kwong Wah Hospital, Hong Kong, SAR China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
China
Erythrocyte Indices*
Female
Humans
Pregnancy
Prenatal Diagnosis*
alpha-Thalassemia / blood,  diagnosis*
beta-Thalassemia / blood,  diagnosis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Heavy-for-date infants: their backgrounds and relationship with gestational diabetes.
Next Document:  Adverse pregnancy outcome following post-chorionic villus sampling amniocentesis compared to chorion...