Document Detail

Ten year survival of a patient with advanced pulmonary hypertension and mixed connective tissue disease treated with immunosuppressive therapy.
MedLine Citation:
PMID:  1491407     Owner:  NLM     Status:  MEDLINE    
Pulmonary hypertension is the most frequent cause of death in patients with mixed connective tissue disease. The pulmonary hypertension is progressive and difficult to treat effectively. These patients experience considerable morbidity secondary to diminished cardiac function. We describe a case in which sequential administration of cyclophosphamide and cyclosporine A favorably altered the clinical and hemodynamic course of this serious complication.
M Dahl; A Chalmers; J Wade; D Calverley; B Munt
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  19     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-03-04     Completed Date:  1993-03-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1807-9     Citation Subset:  IM    
Department of Medicine, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Cyclophosphamide / therapeutic use
Cyclosporine / therapeutic use
Hemodynamics / drug effects
Hypertension, Pulmonary / complications*,  drug therapy*
Immunosuppressive Agents / therapeutic use*
Mixed Connective Tissue Disease / complications*,  drug therapy*
Reg. No./Substance:
0/Immunosuppressive Agents; 50-18-0/Cyclophosphamide; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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