Document Detail


Ten year survival and outcomes in a prospective cohort of new onset Chinese Parkinson's disease patients.
MedLine Citation:
PMID:  22362919     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ObjectiveThe 10 year outcomes and impact of motor and non-motor features on survival of a cohort of new onset Chinese Parkinson's disease (PD) patients were prospectively studied.MethodA cohort of new onset PD patients from 1995 to 2002 was recruited from a regional hospital based movement disorder clinic. Subjects were classified into postural instability gait disorder (PIGD), tremor predominant type or mixed subtypes at presentation. All were evaluated yearly for development of sensory complaints, first significant fall, hallucinations, dementia, postural hypotension, speech disturbances, dysphagia and postural instability persisted during 'on' medication state (PIPon). Mortality and predictors of death were determined.Results171 new onset PD patients were recruited. After a mean follow-up of 11.3±2.6 years, 50 (29%) patients died. The standardised mortality ratio was 1.1 (CI 0.8 to 1.5, p=0.34). 83 (49%) developed dementia, 81 (47%) had psychosis and 103 (60%) had sensory complaints. Postural hypotension was found in 58 (34%) patients, 108 (63%) had PIPon, 101 (59%) had falls, 102 (60%) had dysphagia, 148 (87%) had freezing of gait and 117 (68%) had speech disturbances. 46 (27%) were institutionalised whereas 54 (32%) lived independently. Dementia (HR 5.0, 95% CI 2.1 to 13.0), PIPon (HR 2.8, 95% CI 1.2 to 6.8), older onset (HR 1.05, 1 year increase in age, 95% CI 1.0 to 1.1) and PIGD type (HR 2.1, 95% CI 1.2 to 3.7) were independent predictors of death.Conclusions10 years into PD, a significant proportion of patients developed dopa resistant motor and non-motor features. Older onset, PIGD type, PIPon and dementia had a negative impact on survival. Standardised mortality ratio was 1.1.
Authors:
Man Auyeung; T H Tsoi; Vincent Mok; C M Cheung; C N Lee; R Li; E Yeung
Related Documents :
10712829 - Influence of baseline values on lipids, lipoproteins and fibrinolytic parameters during...
21692839 - Onychophagia-induced longitudinal melanonychia.
22832349 - Metabolome in progression to alzheimer's disease.
22343259 - Catheter ablation of atrioventricular nodal reentrant tachycardia in patients with a pr...
22086519 - The characteristics of stress cardiomyopathy in an ethnically heterogeneous population.
21122659 - Nonoptimal high-density lipoprotein cholesterol levels are highly prevalent in patients...
7600189 - Olfactory testing as an aid in the diagnosis of parkinson's disease: development of opt...
10739559 - Cerebral metabolic changes in patients with a symptomatic occlusion of the internal car...
17015929 - Neuroleptospirosis - revisited: experience from a tertiary care neurological centre fro...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-22
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  -     ISSN:  1468-330X     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A randomised, double blind, placebo controlled trial with vitamin D3 as an add on treatment to inter...
Next Document:  Value of combined midbrain sonography, olfactory and motor function assessment in the differential d...