Document Detail


Ten-year prospective study (clinical spectrum) of childhood Guillain-Barré syndrome in the Arabian peninsula: comparison of outcome in patients in the pre- and post-intravenous immunoglobulin eras.
MedLine Citation:
PMID:  14696904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A prospective study of Guillain-Barré syndrome from January 1992 to December 2001 was undertaken. Intravenous immunoglobulins were used in all patients. All patients were followed up until complete recovery. Various parameters, such as onset of weakness, duration of hospital stay, ventilation requirement, residual deficit, and mortality, were recorded. Acute relapses and fluctuations were also noted. The pattern of this group was compared with patients before 1992, who were not given intravenous immunoglobulins in the Sultanate of Oman. Our data were compared with a few studies prior to 1992 from the medical literature. Our study revealed a definite benefit with intravenous immunoglobulins. The disease course and hospital stay were shortened. Fewer patients needed ventilation. There was no mortality, and the residual deficit was less than 5%. Occasional relapses at a later stage in the course of illness have been noted in acute Guillain-Barré syndrome. However, acute relapse, a new phenomenon that was not seen in the pre-intravenous immunoglobulin era, stood at 11.9%. Intravenous immunoglobulins have made a significant difference in the outcome of Guillain-Barré syndrome, but one has to be aware of acute relapses, which usually occur in the first 2 to 3 weeks after administration.
Authors:
Roshan Koul; Alexander Chacko; Riaz Ahmed; Thomas Varghese; Hashim Javed; Zakia Al-Lamki
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of child neurology     Volume:  18     ISSN:  0883-0738     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-12-30     Completed Date:  2004-03-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  767-71     Citation Subset:  IM    
Affiliation:
Department of Child Health, Sultan Qaboos University Hospital, Al Khod, Sultanate of Oman. roshankoul@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Child, Preschool
Female
Guillain-Barre Syndrome / complications,  drug therapy*,  epidemiology
Humans
Immunoglobulins, Intravenous / therapeutic use*
Infant
Length of Stay
Male
Oman / epidemiology
Prospective Studies
Recovery of Function
Recurrence
Respiration, Artificial
Survival Rate
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Immunoglobulins, Intravenous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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