| Ten year follow up study of lymphocytic gastritis: further evidence on Helicobacter pylori as a cause of lymphocytic gastritis and corpus gastritis. | |
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MedLine Citation:
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PMID: 8567997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To examine the course of lymphocytic gastritis and its relation to Helicobacter pylori (H pylori) infection in a 10 year follow up. METHODS: Ninety six patients were originally examined for dyspepsia in 1981. Gastroscopies with stepwise biopsies were performed on all the patients initially and after an interval of 10 years. RESULTS: Nine per cent of the patients (9/96) had features of lymphocytic gastritis in gastric biopsy at the first examination, and 12.5% (12/96) at the second examination; 7/9 patients (78%) had persistent lymphocytic gastritis during the follow up; in two the diagnostic features of lymphocytic gastritis had disappeared, and five had a new diagnosis of lymphocytic gastritis at the second examination. At the second examination 9/12 lymphocytic gastritis patients (75%) were H pylori positive histologically, while all had specific antibodies to H pylori. The lymphocytic gastritis patients had higher grades of gastritis (p = 0.009), neutrophilic and eosinophilic granulocytes, mononuclear inflammatory cells, and foveolar hyperplasia in the corpus mucosa, but smaller numbers of H pylori, than the H pylori positive patients without lymphocytic gastritis. The appearance of lymphocytic gastritis during the 10 year interval was associated with increases in the grades of corpus gastritis and neutrophilic granulocytes (p = 0.043 for both). During the follow up, the patients with lymphocytic gastritis, but not the H pylori positive patients without lymphocytic gastritis, appeared to have a significant increase in the grade of intestinal metaplasia in the corpus mucosa (p = 0.043). CONCLUSIONS: In some patients H pylori may cause a gastritis that predominates in the corpus and is associated with an increase in the intraepithelial lymphocyte count. This form of gastritis may cause progression of intestinal metaplasia. |
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Authors:
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S Niemel?; T Karttunen; T Kerola; R Karttunen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pathology Volume: 48 ISSN: 0021-9746 ISO Abbreviation: J. Clin. Pathol. Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-03-06 Completed Date: 1996-03-06 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 0376601 Medline TA: J Clin Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1111-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, University Hospital of Oulu, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Follow-Up Studies Gastric Mucosa / microbiology, pathology Gastritis / microbiology*, pathology Helicobacter Infections / pathology* Helicobacter pylori / isolation & purification* Humans Leukocyte Count Lymphocytes / pathology* Male Metaplasia / microbiology Middle Aged Pyloric Antrum / microbiology |
| Comments/Corrections | |
Comment In:
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J Clin Pathol. 1998 Jan;51(1):83-4
[PMID:
9577382
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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