Document Detail


Ten developments in the use of biologicals for systemic lupus erythematosus.
MedLine Citation:
PMID:  23666467     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Belimumab has recently been approved, and several other types of biological therapy with different mechanisms of action are currently in phase II and III studies. This review puts these approaches in context, emphasizing mechanistic categories and clinical trial designs. Most of the promising approaches involve B cell depletion or modulation. Post-approval experience with belimumab is critically reviewed.
Authors:
Daniel J Wallace
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current rheumatology reports     Volume:  15     ISSN:  1534-6307     ISO Abbreviation:  Curr Rheumatol Rep     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-05-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888970     Medline TA:  Curr Rheumatol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  337     Citation Subset:  IM    
Affiliation:
Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA, dwallace@ucla.edu.
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