Document Detail

Ten cases of feline mesothelioma: an immunohistochemical and ultrastructural study.
MedLine Citation:
PMID:  16712862     Owner:  NLM     Status:  MEDLINE    
In the cat only 10 cases of mesothelioma, mainly of the peritoneum, have been previously reported. This paper describes a further 10 cases, eight pleural and two peritoneal, in males and females aged 1-17 years. Histologically, five tumours were epithelial, three fibrosarcomatous and two biphasic. Immunohistochemical markers used in human pathology for the identification of mesotheliomas include vimentin, cytokeratin (CK) AE1/AE3, HBME-1, CK 5/6, calretinin, thrombomodulin, carcinoembryonic antigen (CEA), CD15, E-cadherin and desmin. All 10 feline mesotheliomas were positive for vimentin and CK AE1/AE3, six were positive for HBME-1, two for CK5/6, three for CEA and four for E-cadherin. All were negative for desmin and calretinin. Antibodies to thrombomodulin and CD15 failed to cross-react with feline tissues. Electron microscopy, performed in four cases, revealed microvillar structures, desmosomes and intracytoplasmic lumina, confirming its value as a diagnostic tool. The study showed that mesothelial marker antibodies commonly used in human patients can be used for the diagnosis of feline mesothelioma, preferably as a panel of antibodies rather than only one.
B Bacci; F Morandi; M De Meo; P S Marcato
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-05-18
Journal Detail:
Title:  Journal of comparative pathology     Volume:  134     ISSN:  0021-9975     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-06-05     Completed Date:  2006-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  347-54     Citation Subset:  IM    
Dipartimento di Sanità Pubblica Veterinaria e Patologia Animale, Alma Mater Studiorum Università di Bologna, Via Tolara di Sopra 50, Ozzano Emilia, 40064 Bologna, Italy.
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MeSH Terms
Cat Diseases / pathology*
Cytoplasmic Structures / ultrastructure
Desmosomes / ultrastructure
Immunoenzyme Techniques / veterinary
Mesothelioma / chemistry,  pathology,  veterinary*
Microscopy, Electron, Transmission / veterinary
Microvilli / ultrastructure
Peritoneal Neoplasms / chemistry,  pathology,  veterinary*
Pleura / ultrastructure
Pleural Neoplasms / chemistry,  pathology,  veterinary*
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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