Document Detail

Ten years experience of Salmonella infections in Cambridge, UK.
MedLine Citation:
PMID:  19819256     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Review of all Salmonella infections diagnosed in the Cambridge area over 10 years.
METHODS: All Salmonella enterica isolated in the Clinical Microbiology Laboratory, Addenbrooke's Hospital between 1.1.1999 and 31.12.2008 were included. Patient demographics, serotype and additional relevant details (travel history, resistance-type, phage-type) were recorded.
RESULTS: 1003 episodes of Salmonella gastroenteritis were confirmed by stool culture, representing 88 serotypes. Serotypes Enteritidis (59%), Typhimurium (4.7%), Virchow (2.6%), Newport (1.8%) and Braenderup (1.7%) were the 5 most common isolates. There were an additional 37 invasive Salmonella infections (32 blood cultures, 4 tissue samples, 1 CSF). 13/15 patients with Salmonella Typhi or Salmonella Paratyphi isolated from blood or faeces with an available travel history had returned from the Indian subcontinent. 8/10 S. Typhi or Paratyphi isolates tested had reduced susceptibility to fluoroquinolones (MIC > or = 0.125 mg/L). 7/21 patients with non-typhoidal Salmonella bacteraemia were known to be immunosuppressed.
CONCLUSION: This study describes Salmonella serotypes circulating within a defined geographical area over a decade. Prospective molecular analysis of isolates of S. enterica by multi-locus sequence typing (MLST) and single nucleotide polymorphism (SNP) detection will determine the geo-phylogenetic relationship of isolates within our region.
Nicholas Matheson; Robert A Kingsley; Katherine Sturgess; Sani H Aliyu; John Wain; Gordon Dougan; Fiona J Cooke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-09
Journal Detail:
Title:  The Journal of infection     Volume:  60     ISSN:  1532-2742     ISO Abbreviation:  J. Infect.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-03-22     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  7908424     Medline TA:  J Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  21-5     Citation Subset:  IM    
Copyright Information:
2009 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Bacteremia / diagnosis,  epidemiology
Drug Resistance, Bacterial
Feces / microbiology
Gastroenteritis / epidemiology*,  microbiology
Great Britain / epidemiology
Middle Aged
Salmonella Infections / diagnosis,  epidemiology*
Salmonella enterica / classification,  isolation & purification*
Young Adult
Grant Support
G84/6110//Medical Research Council; //Wellcome Trust

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