| Ten-year clinical follow-up of a cohort of 51 patients with macroprolactinemia establishes it as a benign variant. | |
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MedLine Citation:
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PMID: 20427494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Macroprolactinemia is a common finding in patients with hyperprolactinemia. There are no published long-term follow-up studies. OBJECTIVE: The aim of this study was to describe findings after prolonged follow-up in a previously published cohort of patients with macroprolactinemia. STUDY POPULATION: We studied 51 patients identified as having macroprolactinemia after polyethylene glycol precipitation. DESIGN: Clinical assessment and serum prolactin assay were repeated in 51 patients with macroprolactinemia after a median follow-up of 9.9 yr (range, 9-11 yr). RESULTS: Median age at presentation was 41 yr (range, 18-55 yr). Mean serum prolactin concentration at presentation was 1885 mU/liter, and after follow-up 1370 mU/liter. At follow-up, headache had been experienced in 12 patients (24%) and oligomenorrhea in five (10%). Galactorrhea was present in only two patients (4%). No visual deterioration was noted in 50 patients. One had a transient bitemporal hemianopia. No patients developed an autoimmune condition. Microadenoma had been identified in four patients at presentation with no new pituitary imaging abnormalities identified at follow-up. CONCLUSIONS: During prolonged follow-up, no symptomatic progression was noted in any of our patients. This study suggests that patients with macroprolactinemia and normal concentrations of monomeric prolactin can be reassured, and extended endocrine review of such patients is not required. |
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Authors:
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I R Wallace; N Satti; C H Courtney; H Leslie; P M Bell; S J Hunter; D R McCance; B Sheridan; A B Atkinson |
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Publication Detail:
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Type: Journal Article Date: 2010-04-28 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 95 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-07-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 3268-71 Citation Subset: AIM; IM |
Affiliation:
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Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Fluorescent Antibody Technique Follow-Up Studies Humans Hyperprolactinemia / blood, diagnosis* Pregnancy Prolactin / blood* |
| Chemical | |
Reg. No./Substance:
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9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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