Document Detail


Temporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis.
MedLine Citation:
PMID:  19914744     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alzheimer's disease (AD) can present with non-amnestic clinical syndromes. We investigated whether there is an imaging signature of AD pathology in these atypical subjects. We identified 14 subjects that had pathological AD, a non-amnestic presentation (i.e. atypical AD), and MRI. These subjects were matched to 14 with clinical and pathological AD (i.e. typical AD), 14 with the same non-amnestic presentations with frontotemporal lobar degeneration (FTLD) pathology, and 20 controls. Voxel-based morphometry and region-of-interest (ROI) analysis were used to assess patterns of grey matter loss. Loss was observed in the temporoparietal cortex in both typical and atypical AD, and showed significantly greater loss than FTLD. However, the medial temporal lobes were more severely affected in typical AD and FTLD compared to atypical AD. A ratio of hippocampal and temporoparietal volumes provided excellent discrimination of atypical AD from FTLD subjects. Temporoparietal atrophy may therefore provide a useful marker of the presence of AD pathology even in subjects with atypical clinical presentations, especially in the context of relative sparing of the hippocampus.
Authors:
Jennifer L Whitwell; Clifford R Jack; Scott A Przybelski; Joseph E Parisi; Matthew L Senjem; Bradley F Boeve; David S Knopman; Ronald C Petersen; Dennis W Dickson; Keith A Josephs
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-11-14
Journal Detail:
Title:  Neurobiology of aging     Volume:  32     ISSN:  1558-1497     ISO Abbreviation:  Neurobiol. Aging     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-07-13     Completed Date:  2012-05-17     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1531-41     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / diagnosis*,  pathology*
Atrophy
Biological Markers
Diagnosis, Differential
Disease Progression
Female
Frontotemporal Dementia / diagnosis,  pathology
Hippocampus / pathology*
Humans
Image Processing, Computer-Assisted / methods
Male
Middle Aged
Parietal Lobe / pathology*
Temporal Lobe / pathology*
Grant Support
ID/Acronym/Agency:
C06 RR018898/RR/NCRR NIH HHS; HD49078/HD/NICHD NIH HHS; L30 NS056807/NS/NINDS NIH HHS; L30 NS056807-01/NS/NINDS NIH HHS; L30 NS056807-02/NS/NINDS NIH HHS; P50 AG016574/AG/NIA NIH HHS; P50-AG16574/AG/NIA NIH HHS; R01 AG011378/AG/NIA NIH HHS; R01-AG11378/AG/NIA NIH HHS; U01-AG06786/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers
Comments/Corrections

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