| Temporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis. | |
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MedLine Citation:
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PMID: 19914744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alzheimer's disease (AD) can present with non-amnestic clinical syndromes. We investigated whether there is an imaging signature of AD pathology in these atypical subjects. We identified 14 subjects that had pathological AD, a non-amnestic presentation (i.e. atypical AD), and MRI. These subjects were matched to 14 with clinical and pathological AD (i.e. typical AD), 14 with the same non-amnestic presentations with frontotemporal lobar degeneration (FTLD) pathology, and 20 controls. Voxel-based morphometry and region-of-interest (ROI) analysis were used to assess patterns of grey matter loss. Loss was observed in the temporoparietal cortex in both typical and atypical AD, and showed significantly greater loss than FTLD. However, the medial temporal lobes were more severely affected in typical AD and FTLD compared to atypical AD. A ratio of hippocampal and temporoparietal volumes provided excellent discrimination of atypical AD from FTLD subjects. Temporoparietal atrophy may therefore provide a useful marker of the presence of AD pathology even in subjects with atypical clinical presentations, especially in the context of relative sparing of the hippocampus. |
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Authors:
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Jennifer L Whitwell; Clifford R Jack; Scott A Przybelski; Joseph E Parisi; Matthew L Senjem; Bradley F Boeve; David S Knopman; Ronald C Petersen; Dennis W Dickson; Keith A Josephs |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-11-14 |
Journal Detail:
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Title: Neurobiology of aging Volume: 32 ISSN: 1558-1497 ISO Abbreviation: Neurobiol. Aging Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-07-13 Completed Date: 2012-05-17 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: United States |
Other Details:
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Languages: eng Pagination: 1531-41 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Radiology, Mayo Clinic, Rochester, MN, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / diagnosis*, pathology* Atrophy Biological Markers Diagnosis, Differential Disease Progression Female Frontotemporal Dementia / diagnosis, pathology Hippocampus / pathology* Humans Image Processing, Computer-Assisted / methods Male Middle Aged Parietal Lobe / pathology* Temporal Lobe / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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C06 RR018898/RR/NCRR NIH HHS; HD49078/HD/NICHD NIH HHS; L30 NS056807-01/NS/NINDS NIH HHS; L30 NS056807-02/NS/NINDS NIH HHS; P50 AG016574/AG/NIA NIH HHS; P50-AG16574/AG/NIA NIH HHS; R01 AG011378/AG/NIA NIH HHS; R01-AG11378/AG/NIA NIH HHS; U01-AG06786/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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