Document Detail

Temporary inactivation of the dorsal entorhinal cortex impairs acquisition and retrieval of spatial information.
MedLine Citation:
PMID:  19800978     Owner:  NLM     Status:  MEDLINE    
We tested the effects of temporary inactivation of the dorsal entorhinal cortex on spatial discrimination using a conditioned cue preference (CCP) paradigm. The three phases of the procedure were: pre-exposure: unreinforced exploration of the center platform and two adjacent arms of an eight-arm radial maze; training: rats were confined to the ends of the two arms on alternate days - one arm always contained food and the other never contained food; testing: unreinforced exploration of the center platform and the two arms. Rats that received bilateral infusions of saline into the dorsal entorhinal cortex before the training trials or before the test trial spent significantly more time in the arm that previously contained food than in the arm that never contained food, demonstrating that they had acquired and were able to express information that discriminated between the two adjacent maze arms. In contrast, rats that received bilateral, intra-entorhinal infusions of muscimol, a gamma-aminobutyric acid(a) (GABA(a)) agonist, before either training or testing spent equal amounts of time in the two arms, indicating that they failed to acquire and were unable to express this information. Interactions between the entorhinal cortex and hippocampus in the acquisition and expression of the information required for this discrimination are discussed.
Stephane Gaskin; Norman M White
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Publication Detail:
Type:  Journal Article     Date:  2009-10-02
Journal Detail:
Title:  Neurobiology of learning and memory     Volume:  93     ISSN:  1095-9564     ISO Abbreviation:  Neurobiol Learn Mem     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508166     Medline TA:  Neurobiol Learn Mem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-7     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Inc. All rights reserved.
Center for Studies in Behavioural Neurobiology, Concordia University, Montr?al, Quebec, Canada H4B-1R6.
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MeSH Terms
Entorhinal Cortex / drug effects,  physiology*
GABA Agonists / pharmacology
Maze Learning / drug effects,  physiology*
Mental Recall / drug effects,  physiology*
Muscimol / pharmacology
Neuropsychological Tests
Rats, Long-Evans
Receptors, GABA-A / agonists,  metabolism
Space Perception / drug effects,  physiology*
Time Factors
Reg. No./Substance:
0/GABA Agonists; 0/Receptors, GABA-A; 2763-96-4/Muscimol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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