Document Detail

Temporary elimination of orthostatic hypotension by norepinephrine infusion.
MedLine Citation:
PMID:  22983778     Owner:  NLM     Status:  MEDLINE    
A cardinal manifestation of chronic autonomic failure is neurogenic orthostatic hypotension (OH), which often is associated with supine hypertension, posing a therapeutic dilemma. We report here success in a first step toward development of a "prosthetic baroreceptor system" to maintain blood pressure during orthostasis without worsening supine hypertension. In all of four patients with neurogenic OH, titrated i.v. NE infusion kept directly recorded intra-arterial pressure at or above baseline during progressive head-up tilt. We conclude that titrated i.v. NE infusion temporarily eliminates OH.
David S Goldstein; LaToya Sewell; Courtney Holmes; Sandra Pechnik; André Diedrich; David Robertson
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Intramural     Date:  2012-09-16
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  22     ISSN:  1619-1560     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-19     Completed Date:  2013-04-29     Revised Date:  2014-08-06    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  303-6     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Hypotension, Orthostatic / drug therapy*,  etiology
Infusions, Intra-Arterial
Norepinephrine / therapeutic use*
Parkinson Disease / complications,  drug therapy
Pure Autonomic Failure / complications*,  drug therapy
Tilt-Table Test
Treatment Outcome
Vasoconstrictor Agents / therapeutic use*
Grant Support
Reg. No./Substance:
0/Vasoconstrictor Agents; X4W3ENH1CV/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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