| Temporary elimination of orthostatic hypotension by norepinephrine infusion. | |
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MedLine Citation:
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PMID: 22983778 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A cardinal manifestation of chronic autonomic failure is neurogenic orthostatic hypotension (OH), which often is associated with supine hypertension, posing a therapeutic dilemma. We report here success in a first step toward development of a "prosthetic baroreceptor system" to maintain blood pressure during orthostasis without worsening supine hypertension. In all of four patients with neurogenic OH, titrated i.v. NE infusion kept directly recorded intra-arterial pressure at or above baseline during progressive head-up tilt. We conclude that titrated i.v. NE infusion temporarily eliminates OH. |
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Authors:
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David S Goldstein; Latoya Sewell; Courtney Holmes; Sandra Pechnik; André Diedrich; David Robertson |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-16 |
Journal Detail:
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Title: Clinical autonomic research : official journal of the Clinical Autonomic Research Society Volume: - ISSN: 1619-1560 ISO Abbreviation: Clin. Auton. Res. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9106549 Medline TA: Clin Auton Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892-1620, USA, goldsteind@ninds.nih.gov. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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