Document Detail

Temporally specific extinction of conditioned responses in the rabbit (Oryctolagus cuniculus) nictitating membrane preparation.
MedLine Citation:
PMID:  16187829     Owner:  NLM     Status:  MEDLINE    
Extinguishing a conditioned response (CR) has entailed separating the conditioned stimulus (CS) from the unconditioned stimulus (US). This research reveals that elimination of the rabbit (Oryctolagus cuniculus) nictitating membrane response occurred during continuous CS-US pairings. Initial training contained a mixture of 2 CS-US interstimulus intervals (ISIs): 200 ms and 1,200 ms. The CRs showed double peaks, one for each ISI. When 1 ISI was removed, its CR peak showed the hallmarks of extinction: a decline across sessions, spontaneous recovery between sessions, and rapid reacquisition when the absent ISI was reintroduced. These results support real-time models of conditioning that segment the CS into microstimuli while challenging theories that rely on contextual control, US representations, CS processing, and response inhibition.
E James Kehoe; A Joscelyne
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  119     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-09-28     Completed Date:  2006-01-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1011-22     Citation Subset:  IM    
Copyright Information:
(c) 2005 APA
School of Psychology, University of New South Wales, Sydney, NSW, Australia.
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MeSH Terms
Adaptation, Physiological / physiology
Analysis of Variance
Behavior, Animal
Conditioning, Classical / physiology*
Extinction, Psychological / physiology*
Nictitating Membrane / physiology*
Random Allocation
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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