Document Detail

Temporal variations in the ionic transport across rabbit retinal pigment epithelium.
MedLine Citation:
PMID:  1893768     Owner:  NLM     Status:  MEDLINE    
The potential difference (PD), short circuit current (SCC) and resistance (R) of rabbit retina-retinal pigment epithelium-choroid-sclera preparations were measured in a modified Ussing chamber. The rabbits were kept in 14 hour light/10 hour dark cycle conditions for 14 days: tissues were taken for measurement at 1.5, 6, 13, 20 and 23 hours after the start of the fifteenth light period. Significant variations in PD and SCC were observed 6 hours into the light cycle while the resistance remained constant during the test period. When in a second experiment the fifteenth light period was replaced by darkness, the highest PD and SCC values recorded occurred 12 hours after the time when the light period should have started in the normal light/dark cycle. In a third experiment the fifteenth light period was replaced by darkness and the retina was removed. There were variations in the PD and SCC as in the second experiment but the SCC peak was reduced in amplitude. From these preliminary studies it is suggested that these variations may be circadian in origin and may be related to variations in retinal function.
J Warner; M Boulton; J Mellerio; T Eysteinsson; J Marshall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current eye research     Volume:  10     ISSN:  0271-3683     ISO Abbreviation:  Curr. Eye Res.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-10-24     Completed Date:  1991-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8104312     Medline TA:  Curr Eye Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  513-22     Citation Subset:  IM    
Department of Clinical Ophthalmology, Institute of Ophthalmology, London, UK.
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MeSH Terms
Biological Transport, Active / physiology
Choroid / physiology
Circadian Rhythm / physiology*
Dark Adaptation
Pigment Epithelium of Eye / physiology*
Retina / physiology

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