Document Detail


Temporal variation in the effects of ophthalmic timolol on cardiovascular and respiratory functions in healthy men.
MedLine Citation:
PMID:  9048274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined the effects of ophthalmic timolol and time of administration on cardiovascular and respiratory functions in healthy young male volunteers. Eight participants (mean age +/- standard deviation, 22 +/- 0.9 years) received either 50 microL of 0.5% timolol or placebo in the lower conjunctival sacs of both eyes in the morning or evening. Intraocular pressure, blood pressure, heart rate, and respiratory functions, including percent forced expiratory volume in 1 second and peak expiratory flow rate, were then measured for 3 hours after drug administration. Timolol reduced intraocular pressure and cardiovascular function at both administration times. However, a timolol-induced reduction in respiratory function was observed only in the evening: percent forced expiratory volume in 1 second, peak expiratory flow rate, and expiratory flow rate at 75% vital capacity were reduced by 3%, 7%, and 12%, respectively, 3 hours after administration. These results indicate that ophthalmic timolol reduces cardiovascular and respiratory functions in healthy young male subjects and that bronchial sensitivity to timolol differs between morning and evening.
Authors:
M H Umetsuki; T Kotegawa; K Nakamura; S Nakano; K Nakatsuka
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  37     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-05-01     Completed Date:  1997-05-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  58-63     Citation Subset:  IM    
Affiliation:
Department of Clinical Pharmacology and Therapeutics, Oita Medical University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / therapeutic use*
Adult
Analysis of Variance
Blood Pressure / drug effects
Cross-Over Studies
Double-Blind Method
Female
Forced Expiratory Volume / drug effects
Glaucoma / drug therapy*
Heart Rate / drug effects
Humans
Male
Middle Aged
Ophthalmic Solutions
Timolol / therapeutic use*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Ophthalmic Solutions; 26839-75-8/Timolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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