Document Detail


Temporal trend in relative risk of second primary colorectal cancer.
MedLine Citation:
PMID:  16771959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Patients with colorectal cancer (CRC) are at a higher risk for developing a second primary. Factors (such as survival rate, rate of receipt of surveillance procedures, and the overall incidence of CRC) with potential impact on the risk for second primary CRC have changed over the last three decades. Thus, it is likely that the risk for second primary CRC also has changed over the years. OBJECTIVES: We used the Surveillance, Epidemiology, and End Results public-use database to assess whether the relative risk of second primary CRC has changed in patients with initial primary CRC. METHODS: The temporal trend in the standardized incidence ratio (SIR) for a second primary CRC was estimated. Also, the clinical features of the second primary CRC were compared in two subgroups based on the year of diagnosis of the first primary CRC: Group A (1973-1977) and Group B (1988-1992). RESULTS: During the period of 1973 to 2002, 216,751 patients developed a primary CRC and over a follow-up period of 1,250,687 person-years, 5,595 of these patients developed a second primary CRC, with an SIR of 1.36 (95% CI 1.32-1.39). In a Cox regression model, the period of diagnosis of the first primary CRC was an independent risk factor for a subsequent primary CRC, with a relative hazard of second colon cancer in Group B compared with Group A being 1.18 (95% CI 1.06-1.31), after controlling for age at diagnosis, site, stage of first primary, gender, and race. CONCLUSION: The relative risk of the second primary CRC has increased since early 1990s. These subsequent cancers are being diagnosed at an earlier stage. Increased surveillance may be one of the factors contributing to this temporal difference.
Authors:
Ananya Das; Amitabh Chak; Gregory S Cooper
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  101     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-14     Completed Date:  2006-08-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1342-7     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology, Mayo Clinic Scottsdale, Scottsdale, Arizona 85259, and Division of Gastroenterology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Colorectal Neoplasms / epidemiology,  pathology*
Female
Humans
Incidence
Male
Middle Aged
Neoplasms, Second Primary / epidemiology,  pathology*
Poisson Distribution
Proportional Hazards Models
Risk Factors
SEER Program
Survival Rate
Time Factors
United States / epidemiology
Grant Support
ID/Acronym/Agency:
K05 CA90677/CA/NCI NIH HHS; K24 DK028000/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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