Document Detail

Temporal self-organization in biochemical systems: periodic behavior vs. chaos.
MedLine Citation:
PMID:  6312816     Owner:  NLM     Status:  MEDLINE    
The patterns of temporal self-organization in regulated biochemical systems are examined. Simple periodic oscillations are the most frequent type of such organization, as exemplified by glycolytic oscillations in yeast and muscle and by the periodic synthesis of adenosine 3',5'-cyclic monophosphate in Dictyostelium discoideum amoebas. These phenomena originate, respectively, from the periodic operation of the product-activated phosphofructokinase and adenylate cyclase reactions. The analysis of a model for a multiply regulated biochemical system shows more complex oscillatory phenomena, e.g., the coexistence between two stable periodic regimes for the same set of parameter values (birhythmicity) and chaos. The latter phenomenon of aperiodic oscillations occurs in a narrow range of parameter values and is much less frequent than simple or complex periodic behavior. It is suggested that a sufficient condition for the occurrence of birhythmicity and chaos in a regulated biological system subjected to a constant environment (i.e., in the absence of periodic forcing) may be the simultaneous presence and interaction of two mechanisms capable of producing oscillations.
A Goldbeter; O Decroly
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  245     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R478-83     Citation Subset:  IM    
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MeSH Terms
Cyclic AMP / physiology
Dictyostelium / physiology
Enzymes / metabolism
Models, Biological*
Phosphofructokinase-1 / metabolism
Reg. No./Substance:
0/Enzymes; 60-92-4/Cyclic AMP; EC

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