| Temporal resolution properties of human auditory cortex: reflections in the neuromagnetic auditory evoked M100 component. | |
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MedLine Citation:
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PMID: 16403467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous work has provided evidence for a brief, finite ( approximately 35 ms) temporal window of integration (TWI) in M100 formation, during which stimulus attributes are accumulated in processes leading to the M100 peak. Here, we investigate resolution within the TWI by recording responses to tones containing silent gaps (0-20 ms). Gaps were inserted in 1 kHz tones in 2 conditions: +10 ms post-onset (10 ms masker) wherein the masker and gap of longest duration (20 ms) were contained within the initial 35 ms of the stimulus and +40 ms (40 ms masker) wherein all gaps were inserted +40 ms post-onset. Tones were presented binaurally and responses sampled from both hemispheres in 12 adults using a twin 37-channel biomagnetometer (MAGNES-II, BTi, San Diego, CA). Results--10 ms masker: M100 latency was prolonged and amplitude decreased as a function of gap duration, even with the shortest duration (2 ms) gap, indicating that integrative processes underlying M100 formation are sensitive to fine-grained discontinuities within a brief, finite TWI. Results--40 ms masker: M100 latency and amplitude were unaffected by gaps inserted at +40 ms, providing further evidence for an M100 TWI of <40 ms. CONCLUSION: within a brief integrative window in M100 formation, population-level responses are sensitive to discontinuities in sounds on a scale corresponding to psychophysical detection thresholds and minimum detectable gap thresholds in single unit recordings. Cumulatively, results provide evidence that M100 resolution for brief fluctuations in sounds reflects temporal acuity properties that are both intrinsic to the auditory system and critical to the accurate perception of speech. |
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Authors:
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Nicole Gage; Timothy P L Roberts; Gregory Hickok |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-01-05 |
Journal Detail:
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Title: Brain research Volume: 1069 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2006-01-30 Completed Date: 2006-06-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 166-71 Citation Subset: IM |
Affiliation:
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Department of Cognitive Sciences, 3151 Social Science Plaza A, University of California, Irvine, CA 92697-5100, USA. ngage@uci.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation
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methods Adult Auditory Cortex / physiology* Auditory Perception / physiology Brain Mapping* Evoked Potentials, Auditory / physiology*, radiation effects Female Humans Magnetoencephalography* Male Middle Aged Reaction Time / physiology, radiation effects Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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DC-03681/DC/NIDCD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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