Document Detail


Temporal relationships between wall motion, intraluminal pressure and flow in the isolated rabbit small intestine.
MedLine Citation:
PMID:  21193528     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Intraluminal manometry is a tool commonly used to record motility in the human digestive tract. The recorded signal results from a combination of factors including the hydrodynamic pressure transmitted through the intestinal contents due to the contraction of the gut wall and the force of the gut wall acting on the sensors in regions of a luminal occlusion. However the actual relationships that exist between gut wall contraction, the measured intraluminal pressure and the resultant flow have not been directly addressed. Methods Spatio-temporal video maps of diameter and intraluminal pressure were created from isolated segments of rabbit small intestine, using video recording and high-resolution fiber optic manometry. Results: In the un-stimulated gut, longitudinal muscle contractions were the only detectable motor pattern; circular muscle contractions were elicited by distension or erythromycin (1µM). Longitudinal muscle contractions were not lumen-occlusive, caused measurable low amplitude changes in pressure, which were not propulsive. Localized non-propagating circular muscle contractions caused small localized, non-propagating peaks of intraluminal pressure. Propagating contractions of circular muscle evoked larger, propagating pressure changes that were associated with outflow. Propagating circular muscle contractions often caused dilation of aboral receiving segments, corresponding to "common cavities"; these were propulsive despite their low intraluminal pressure. The highest amplitude pressure events were caused by lumen-occlusive circular muscle contractions that squeezed directly against the catheter. Conclusions. These data allow us to define the complex relationships that exist between wall motion, intraluminal pressure and flow. A strong correlation between circular and longitudinal muscle contraction and intraluminal pressure was demonstrated. Common cavity pressure events, caused by propulsion of content by circular muscle contractions into a receptive segment were often of low amplitude but highly propulsive. Studies of motility in isolated preparations, combined with manometry can assist the interpretation of pressure recordings in vivo.
Authors:
Philip G Dinning; John W Arkwright; Marcello Costa; Lukaz Wiklendt; Grant W Hennig; Simon Jh Brookes; Nick J Spencer
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-30
Journal Detail:
Title:  American journal of physiology. Gastrointestinal and liver physiology     Volume:  -     ISSN:  1522-1547     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901227     Medline TA:  Am J Physiol Gastrointest Liver Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1St. George Hospital.
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