| Temporal relation of changes in regional coronary flow and myocardial lactate and nucleoside metabolism during pacing-induced ischemia. | |
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MedLine Citation:
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PMID: 3788806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The temporal relation between myocardial lactate and hypoxanthine metabolism and regional changes in krypton-81m perfusion during pacing-induced ischemia was studied in 17 patients with coronary artery disease (CAD). During incremental atrial pacing, lactate production and hypoxanthine release occurred early and simultaneously, accompanied by ST-segment changes, but before angina and only few minutes after a significant (17%) reduction in krypton-81m perfusion in areas with more than 90% luminal diameter reduction. During maximal pacing heart rates, krypton-81m distribution decreased to 68 +/- 7% of control in areas with more than 90% diameter reduction and to 80 +/- 4% in 70 to 90% reduction (both p less than 0.05 vs control). Maximal lactate production occurred 15 seconds after pacing (extraction -15 +/- 7% vs 16 +/- 2% during control, p less than 0.05) and peak hypoxanthine release 1 minute after pacing (delta arteriovenous -2.64 +/- 0.8 microM vs 0.08 +/- 0.21 microM during control, p less than 0.05). Krypton-81m perfusion decreased in 20 of the 21 CAD areas. Angina, ST-segment changes, hemodynamic alterations and lactate production occurred in 15, 14, 9 and 15 patients, respectively. In contrast, hypoxanthine release was found in all cases. After pacing, lactate production and all general indexes of ischemia persisted for only 2 to 3 minutes. In contrast, krypton-81m perfusion was still significantly reduced 5 minutes after pacing and was only accompanied by hypoxanthine release (delta arteriovenous -1.41 +/- 0.6 microM, p less than 0.05 vs control).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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W J Remme; R van den Berg; M Mantel; P H Cox; D C van Hoogenhuyze; X H Krauss; C J Storm; D A Kruyssen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of cardiology Volume: 58 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1986 Dec |
Date Detail:
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Created Date: 1987-01-14 Completed Date: 1987-01-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1188-94 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cardiac Pacing, Artificial* Coronary Circulation* Coronary Disease / physiopathology* Female Humans Hypoxanthine Hypoxanthines / metabolism* Krypton / diagnostic use Lactates / metabolism* Lactic Acid Male Middle Aged Myocardium / metabolism* Radioisotopes / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Hypoxanthines; 0/Lactates; 0/Radioisotopes; 50-21-5/Lactic Acid; 68-94-0/Hypoxanthine; 7439-90-9/Krypton |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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