Document Detail


Temporal pulmonary function changes in cervical cord injury.
MedLine Citation:
PMID:  3977564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Temporal changes in pulmonary function (PF) in subjects with complete cervical cord transection occur in two stages. The first, extending from the acute to post-acute periods, is characterized by relatively rapid increases in the following: vital, inspiratory, and total lung capacities (VC, IC, and TLC, respectively), and inspiratory and expiratory airflows coupled with decreases in functional residual capacity (FRC). Second stage changes--from the post-acute period on--are more gradual, with both VC increase and FRC decrease continuing while TLC and ventilatory indices remain unchanged. The initial stage appears to be caused in part by functional respiratory muscle return coincident with resolution of inflammation and edema above the injury level. Altered respiratory mechanics also contribute to these early changes and the continuing later changes. Mechanical changes in the lung are probably both decreased compliance (which decreases FRC) and increased airway resistance (which diminishes airflow). Chest wall changes, resulting from returning spinal cord reflexes, affect PF via: (1) increased rib cage stability, leading to a more effective transduction of diaphragmatic displacement into lung volume, and (2) abdominal and expiratory intercostal spasticity, which could limit maximum inspiration. The net effect of these changes, however, may eventually lead to chronic hypoventilation.
Authors:
F Haas; K Axen; H Pineda; D Gandino; A Haas
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  66     ISSN:  0003-9993     ISO Abbreviation:  Arch Phys Med Rehabil     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-04-12     Completed Date:  1985-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  139-44     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Diaphragm / physiopathology
Female
Humans
Lung / physiopathology*
Male
Middle Aged
Quadriplegia / physiopathology
Respiratory Function Tests
Spinal Cord Injuries / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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