Document Detail

Temporal pattern of food intake not a factor in the retardation of aging processes by dietary restriction.
MedLine Citation:
PMID:  7814779     Owner:  NLM     Status:  MEDLINE    
Long-term dietary restriction programs which retard aging processes in rodents usually involve meal eating rather than the nibbling pattern of food intake of ad libitum fed rodents. Thus, the possibility arises that the antiaging action may at least in part result from an altered temporal pattern of food intake. This possibility was investigated using male F344 rats maintained on the following dietary regimens: Group A rats fed ad libitum; Group B rats fed 60% the ad libitum intake in a single meal at 1500 h; Group B-2 rats fed 60% of the ad libitum intake in two meals (0700 h and 1500 h). The diurnal pattern of plasma corticosterone concentration differed among the groups as did that of the plasma glucose concentration. The median length of life and age of tenth percentile survivors were similar for Group B and B-2 rats and much greater than those for Group A rats. Both modes of dietary restriction influenced age-associated disease processes in a similar fashion. Thus, although the temporal pattern of food intake influenced circadian rhythms of food-restricted rats, it did not significantly affect the antiaging action.
E J Masoro; I Shimokawa; Y Higami; C A McMahan; B P Yu
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  50A     ISSN:  1079-5006     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-02-07     Completed Date:  1995-02-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  B48-53     Citation Subset:  IM    
Department of Physiology, University of Texas Health Science Center at San Antonio.
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MeSH Terms
Aging / pathology,  physiology*
Blood Glucose / analysis
Circadian Rhythm
Corticosterone / blood
Energy Intake*
Feeding Behavior*
Rats, Inbred F344
Time Factors
Grant Support
Reg. No./Substance:
0/Blood Glucose; 50-22-6/Corticosterone

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