| Temporal optimisation of microfluidic colourimetric sensors using a novel multiplexed stop-flow architecture. | |
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MedLine Citation:
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PMID: 21563778 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We present two microfluidic architectures (continuous flow, and multiplexed stop flow) for miniaturized colorimetric nutrient sensors. These systems are compared with respect to the temporal response (for optimization of sampling rate) and reduction of reagent consumption. The continuous-flow system is capable of a sampling rate of 60 h-1, limited by Taylor dispersion. The novel multiplexed stop-flow (MSF) microsystem architecture is not limited by dispersion. A demonstration MSF system consisting of two stop-flow channels is presented. This requires 12.6 s to load each sample into a measurement channel and when scaled would be capable of a throughput of 285 h-1 (with full color development). The MSF architecture is manufactured in PMMA/Viton®/PMMA, utilizes on-chip valving and is scalable, thereby permitting sampling at much faster rates (sub-second). Either system is capable of remote deployment and continuous measurement of nutrient concentrations. The MSF system is particularly suited for applications requiring high temporal or spatial resolution; such as from moving vehicles. |
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Authors:
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Iain Ogilvie; Vincent Joseph Sieben; Matthew C Mowlem; Hywel Morgan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-12 |
Journal Detail:
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Title: Analytical chemistry Volume: - ISSN: 1520-6882 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370536 Medline TA: Anal Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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