Document Detail


Temporal lobe regions on magnetic resonance imaging identify patients with early Alzheimer's disease.
MedLine Citation:
PMID:  8363449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The goal of the study was to examine the volume of selected brain regions in a group of mildly impaired patients with Alzheimer's disease (AD). Five regions were selected for analysis, all of which have been reported to show substantial change in the majority of patients with AD at some time in the course of disease. DESIGN: Case-control study with the experimenter "blinded." SETTING: Hospital-based magnetic resonance imaging center. PARTICIPANTS: Fifteen subjects, eight patients with the diagnosis of probable dementia of the Alzheimer type made in concordance with National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association criteria and seven age-matched healthy control subjects. RESULTS: Three of the volumetric measures were significantly different between patients with AD and controls: the hippocampus, the temporal horn of the lateral ventricles, and the temporal lobe. Two of the measures did not significantly differentiate patients with AD and controls: the amygdala and the basal forebrain. A discriminant function analysis demonstrated that a linear combination of the volumes of the hippocampus and the temporal horn of the lateral ventricles differentiated 100% of the patients and controls from one another. CONCLUSIONS: The results suggest that the hippocampus and the temporal horn of the lateral ventricles may be useful as antemortem markers of AD in mildly impaired patients.
Authors:
R J Killiany; M B Moss; M S Albert; T Sandor; J Tieman; F Jolesz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of neurology     Volume:  50     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-09-28     Completed Date:  1993-09-28     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  949-54     Citation Subset:  AIM; IM    
Affiliation:
Department of Anatomy and Neurobiology, Boston University School of Medicine, MA 02118.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / epidemiology,  pathology*
Amygdala / pathology
Case-Control Studies
Cerebral Ventricles / pathology
Female
Hippocampus / pathology
Humans
Magnetic Resonance Imaging*
Male
Middle Aged
Prosencephalon / pathology
Temporal Lobe / pathology*
Grant Support
ID/Acronym/Agency:
P01-AG04953/AG/NIA NIH HHS; T32-NS07152/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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