Document Detail

Temporal lobe magnetic resonance spectroscopic imaging following selective amygdalohippocampectomy for treatment-resistant epilepsy.
MedLine Citation:
PMID:  15932349     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Magnetic resonance spectroscopic imaging (MRSI) may show circumscribed or extensive decreased brain N-acetyl aspartate (NAA)/creatine and phosphocreatine (Cr) in epilepsy patients. We compared temporal lobe MRSI in patients seizure-free (SzF) or with persistent seizures (PSz) following selective amygdalohippocampectomy (SAH) for medically intractable mesial temporal lobe epilepsy (mTLE). We hypothesized that PSz patients had more extensive temporal lobe metabolite abnormalities than SzF patients. MATERIALS AND METHODS: MRSI was used to study six regions of interest (ROI) in the bilateral medial and lateral temporal lobes in 14 mTLE patients following SAH and 11 controls. RESULTS: PSz patients had more temporal lobe ROI with abnormally low NAA/Cr than SzF patients, including the unoperated hippocampus and ipsilateral lateral temporal lobe. CONCLUSION: Postoperative temporal lobe MRSI abnormalities are more extensive if surgical outcome following SAH is poor. MRSI may be a useful tool to improve selection of appropriate candidates for SAH by identifying patients requiring more intensive investigation prior to epilepsy surgery. Future prospective studies are needed to evaluate the utility of MRSI, a predictor of successful outcome following SAH.
D C Spencer; J Szumowski; D F Kraemer; P Y Wang; K J Burchiel; D M Spielman
Related Documents :
8687189 - Language cortex representation: effects of developmental versus acquired pathology.
3593059 - Electrophysiologic pathologic correlations in patients with complex partial seizures.
8848199 - Quantitative hippocampal mri and intractable temporal lobe epilepsy.
16014649 - Analysis of shape and positioning of the hippocampal formation: an mri study in patient...
18205819 - Surgical outcome of patients with mesial temporal lobe epilepsy related to hippocampal ...
18316209 - Adult-onset epilepsy associated with dysembryoplastic neuroepithelial tumors.
1918699 - Atrial septal aneurysm and stroke: a transesophageal echocardiographic study.
17364349 - The role of flexible autofluorescence laryngoscopy in the diagnosis of malignant lesion...
16820809 - Evaluation of swallowing patterns of the tongue using real-time b-mode sonography.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  112     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-03     Completed Date:  2005-08-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  6-12     Citation Subset:  IM    
Copyright Information:
Copyright Blackwell Munksgaard 2005.
Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amygdala / metabolism*,  physiopathology,  surgery
Aspartic Acid / analogs & derivatives*,  analysis,  metabolism
Brain Chemistry / physiology*
Creatine / analysis,  metabolism
Epilepsy, Temporal Lobe / diagnosis*,  metabolism*,  surgery
Hippocampus / metabolism*,  physiopathology,  surgery
Magnetic Resonance Spectroscopy
Middle Aged
Neocortex / metabolism,  physiopathology
Neurosurgical Procedures
Phosphocreatine / analysis,  metabolism
Predictive Value of Tests
Reference Values
Treatment Outcome
Grant Support
Reg. No./Substance:
56-84-8/Aspartic Acid; 57-00-1/Creatine; 67-07-2/Phosphocreatine; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Efficacy of desmopressin in patients with multiple sclerosis suffering from bladder dysfunction: a m...
Next Document:  Predictors of headache 22 years after hospitalization for head injury.