| Temporal lobe magnetic resonance spectroscopic imaging following selective amygdalohippocampectomy for treatment-resistant epilepsy. | |
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MedLine Citation:
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PMID: 15932349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Magnetic resonance spectroscopic imaging (MRSI) may show circumscribed or extensive decreased brain N-acetyl aspartate (NAA)/creatine and phosphocreatine (Cr) in epilepsy patients. We compared temporal lobe MRSI in patients seizure-free (SzF) or with persistent seizures (PSz) following selective amygdalohippocampectomy (SAH) for medically intractable mesial temporal lobe epilepsy (mTLE). We hypothesized that PSz patients had more extensive temporal lobe metabolite abnormalities than SzF patients. MATERIALS AND METHODS: MRSI was used to study six regions of interest (ROI) in the bilateral medial and lateral temporal lobes in 14 mTLE patients following SAH and 11 controls. RESULTS: PSz patients had more temporal lobe ROI with abnormally low NAA/Cr than SzF patients, including the unoperated hippocampus and ipsilateral lateral temporal lobe. CONCLUSION: Postoperative temporal lobe MRSI abnormalities are more extensive if surgical outcome following SAH is poor. MRSI may be a useful tool to improve selection of appropriate candidates for SAH by identifying patients requiring more intensive investigation prior to epilepsy surgery. Future prospective studies are needed to evaluate the utility of MRSI, a predictor of successful outcome following SAH. |
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Authors:
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D C Spencer; J Szumowski; D F Kraemer; P Y Wang; K J Burchiel; D M Spielman |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 112 ISSN: 0001-6314 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-06-03 Completed Date: 2005-08-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 6-12 Citation Subset: IM |
Copyright Information:
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Copyright Blackwell Munksgaard 2005. |
Affiliation:
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Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA. spencerd@ohsu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amygdala / metabolism*, physiopathology, surgery Aspartic Acid / analogs & derivatives*, analysis, metabolism Brain Chemistry / physiology* Creatine / analysis, metabolism Epilepsy, Temporal Lobe / diagnosis*, metabolism*, surgery Female Hippocampus / metabolism*, physiopathology, surgery Humans Magnetic Resonance Spectroscopy Male Middle Aged Neocortex / metabolism, physiopathology Neurosurgical Procedures Phosphocreatine / analysis, metabolism Predictive Value of Tests Reference Values Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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CA48269/CA/NCI NIH HHS; RR09784/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-84-8/Aspartic Acid; 57-00-1/Creatine; 67-07-2/Phosphocreatine; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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