Document Detail

Temporal lobe lesion-induced obesity in rats: an anatomical investigation of the posterior amygdala and hippocampal formation.
MedLine Citation:
PMID:  8778875     Owner:  NLM     Status:  MEDLINE    
Bilateral lesions centered in the posterodorsal amygdala of female rats resulted in hyperphagia and excessive weight gain (mean = 65.3 g in 20 days compared to 6.8 g for control animals). The brain damage always extended posteriorly into the ventral hippocampal formation. However, lesions that were confined to the ventral hippocampus or amygdalohippocampal area had no effect on daily food intake or body weight, nor did lesions at any other hippocampal site. In a previous study, lesions of the basolateral, corticomedial, and anterior groups of amygdaloid nuclei failed to affect food intake or body weight. It is concluded that the posterodorsal aspect of the amygdala is the critical site for this experimentally induced obesity syndrome. New coordinates for the effective site are presented.
B M King; E R Arceneaux; J T Cook; A L Benjamin; G F Alheid
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  59     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:    1996 Apr-May
Date Detail:
Created Date:  1996-09-13     Completed Date:  1996-09-13     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  843-8     Citation Subset:  IM    
Department of Psychology, University of New Orleans, LA 70148, USA.
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MeSH Terms
Amygdala / anatomy & histology*,  physiology
Eating / drug effects,  physiology
Hippocampus / anatomy & histology*,  physiology
Obesity / physiopathology*
Temporal Lobe / anatomy & histology*,  physiology*
Weight Gain / physiology

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