Document Detail

Temporal lobe epilepsy in infants and children.
MedLine Citation:
PMID:  9628189     Owner:  NLM     Status:  MEDLINE    
Temporal lobe epilepsy in adults and adolescents is a fairly homogeneous syndrome, both in terms of seizure semiology and in terms of its pathology, and it has been studied extensively. Temporal lobe epilepsy in infants and young children has begun to receive increasing attention in recent years, and a different clinico-pathological picture has emerged. Clinically, the concept of complex partial seizures, which may be useful in adults, is difficult to apply to infants, since it is often not possible to assess impairment of consciousness in this age group. The main distinctive features of complex partial seizures of temporal lobe origin in infants are (1) a predominance of behavioral arrest with possible impairment of consciousness, (2) no identifiable aura, (3) automatisms that are discrete and mostly orofacial, (4) more prominent convulsive activity, and (5) a longer duration (more than 1 min). In addition, seizures of temporal lobe origin in infants may appear clinically generalized, such as infantile spasms or generalized tonic seizures, or can occasionally represent a benign syndrome. The neuropathological findings of temporal lobe epilepsy in infants differ even more than the clinical seizure semiology. In contrast to adult and adolescent patients, mesial temporal sclerosis is a rare finding in infants, in whom the pathological abnormalities associated with seizures of temporal lobe origin consist mostly of dysplasias, migrational disorders, hamartomas, and low-grade tumors such as gangliogliomas. Mesial temporal sclerosis is seen more often in older children than in infants, and its pathogenesis remains a subject of controversy.
B F Bourgeois
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Brain & development     Volume:  20     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-08-13     Completed Date:  1998-08-13     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  135-41     Citation Subset:  IM    
Washington University, Department of Neurology, St. Louis Children's Hospital, MO 63110, USA.
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MeSH Terms
Child, Preschool
Epilepsy, Complex Partial / physiopathology
Epilepsy, Temporal Lobe / diagnosis,  physiopathology*
Temporal Lobe / pathology

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