Document Detail

Temporal lobe changes in early, untreated Parkinson's disease.
MedLine Citation:
PMID:  19606493     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine if focal cortical abnormalities may occur in early Parkinson's disease (PD). We studied 26 untreated patients with early PD and 14 healthy control subjects, with cognitive screening and magnetic resonance imaging (MRI). Voxel-based morphometry was used to assess for the presence of localized cortical grey matter (GM) and/or subcortical white matter (WM) changes. Patient and control groups showed no differences in age or gender distribution. Females had a greater GM% than males (P = 0.001). Comparison of patients and controls revealed no difference in local GM volumes. In PD, however, there was decreased WM volume in the anterior right fusiform gyrus and superior temporal gyrus. There were no correlations between the California Verbal Learning Test long delay free recall, Judgment of Line Orientation, Trail Making A or B and either the GM or WM localized volumes. These results suggest that right anterior temporal lobe changes occur in untreated patients with PD. The earliest changes may occur in subcortical white matter rather than temporal cortex.
W R Wayne Martin; Marguerite Wieler; Myrlene Gee; Richard Camicioli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  24     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-03     Completed Date:  2010-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1949-54     Citation Subset:  IM    
Division of Neurology, University of Alberta, Edmonton, Alberta, Canada.
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MeSH Terms
Analysis of Variance
Brain Mapping
Cognition Disorders / etiology,  pathology
Disease Progression
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Middle Aged
Neuropsychological Tests
Parkinson Disease / complications,  pathology*
Sex Factors
Temporal Lobe / pathology*
Grant Support
//Canadian Institutes of Health Research

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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