Document Detail

Temporal lobe abnormalities in first-episode psychosis.
MedLine Citation:
PMID:  12091206     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The nature and time course of temporal lobe abnormalities in psychotic illness remain controversial. Confounds include disease chronicity, gender, and handedness. The present study investigated temporal substructures in right-handed male patients experiencing their first episode of psychotic illness. METHOD: Magnetic resonance imaging scans were obtained for 25 minimally treated patients experiencing their first psychotic episode and 16 healthy comparison subjects. Group differences in volumes of the hippocampus, amygdala, planum temporale, and Heschl's gyrus were tested. RESULTS: The patients had smaller bilateral hippocampal and left planum temporale volumes than the comparison subjects. Paranoid and nonparanoid patients differed in left amygdala volume. CONCLUSIONS: The authors conclude that bilateral hippocampal and left planum temporale abnormalities are present near the onset of psychosis.
Alex Sumich; Xavier A Chitnis; Dominic G Fannon; Séamus O'Ceallaigh; Victor C Doku; Abi Falrowicz; Nicolette Marshall; Vallakalil M Matthew; Mark Potter; Tonmoy Sharma
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  159     ISSN:  0002-953X     ISO Abbreviation:  Am J Psychiatry     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-01     Completed Date:  2002-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1232-5     Citation Subset:  AIM; IM    
Clinical Neuroscience Research Centre, Stonehouse Hospital, Cotton Lane, Dartford, Kent DA2 6AU, UK.
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MeSH Terms
Amygdala / anatomy & histology
Functional Laterality / physiology
Hippocampus / anatomy & histology
Magnetic Resonance Imaging / statistics & numerical data
Psychiatric Status Rating Scales / statistics & numerical data
Psychotic Disorders / diagnosis*,  psychology
Schizophrenia / diagnosis
Schizophrenia, Paranoid / diagnosis,  psychology
Schizophrenic Psychology
Sex Factors
Temporal Lobe / anatomy & histology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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