Document Detail


Temporal lobe abnormalities in first-episode psychosis.
MedLine Citation:
PMID:  12091206     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The nature and time course of temporal lobe abnormalities in psychotic illness remain controversial. Confounds include disease chronicity, gender, and handedness. The present study investigated temporal substructures in right-handed male patients experiencing their first episode of psychotic illness. METHOD: Magnetic resonance imaging scans were obtained for 25 minimally treated patients experiencing their first psychotic episode and 16 healthy comparison subjects. Group differences in volumes of the hippocampus, amygdala, planum temporale, and Heschl's gyrus were tested. RESULTS: The patients had smaller bilateral hippocampal and left planum temporale volumes than the comparison subjects. Paranoid and nonparanoid patients differed in left amygdala volume. CONCLUSIONS: The authors conclude that bilateral hippocampal and left planum temporale abnormalities are present near the onset of psychosis.
Authors:
Alex Sumich; Xavier A Chitnis; Dominic G Fannon; Séamus O'Ceallaigh; Victor C Doku; Abi Falrowicz; Nicolette Marshall; Vallakalil M Matthew; Mark Potter; Tonmoy Sharma
Related Documents :
10435506 - Magnetic resonance imaging findings in corticobasal degeneration.
2465056 - Alternating antagonism between two languages with successive recovery of a third in a t...
9147496 - Proton magnetic resonance spectroscopy of the temporal lobes in schizophrenics and norm...
14692906 - Usefulness of [11c]methionine pet in the diagnosis of dysembryoplastic neuroepithelial ...
7844746 - Disclusion time measurement studies: a comparison of disclusion time between chronic my...
9175046 - Autonomic nervous system and adrenergic receptors in chronic hypotensive haemodialysis ...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  159     ISSN:  0002-953X     ISO Abbreviation:  Am J Psychiatry     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-01     Completed Date:  2002-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1232-5     Citation Subset:  AIM; IM    
Affiliation:
Clinical Neuroscience Research Centre, Stonehouse Hospital, Cotton Lane, Dartford, Kent DA2 6AU, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Amygdala / anatomy & histology
Functional Laterality / physiology
Hippocampus / anatomy & histology
Humans
Magnetic Resonance Imaging / statistics & numerical data
Male
Psychiatric Status Rating Scales / statistics & numerical data
Psychotic Disorders / diagnosis*,  psychology
Schizophrenia / diagnosis
Schizophrenia, Paranoid / diagnosis,  psychology
Schizophrenic Psychology
Sex Factors
Temporal Lobe / anatomy & histology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Antipsychotic drug treatment in the prodromal phase of schizophrenia.
Next Document:  Depressive symptoms in adolescence as predictors of early adulthood depressive disorders and maladju...