| Temporal evolution of water diffusion parameters is different in grey and white matter in human ischaemic stroke. | |
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MedLine Citation:
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PMID: 15548489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Our purpose was to investigate whether differences exist in the values and temporal evolution of mean diffusivity (<D>) and fractional anisotropy (FA) of grey and white matter after human ischaemic stroke. METHODS: Thirty two patients with lesions affecting both grey and white matter underwent serial diffusion tensor magnetic resonance imaging (DT-MRI) within 24 hours, and at 4-7 days, 10-14 days, 1 month, and 3 months after stroke. Multiple small circular regions of interest (ROI) were placed in the grey and white matter within the lesion and in the contralateral hemisphere. Values of <D>[grey], <D>[white], FA[grey] and FA[white] were measured in these ROI at each time point and the ratios of ischaemic to normal contralateral values (<D>R and FAR) calculated. RESULTS: <D> and FA showed different patterns of evolution after stroke. After an initial decline, the rate of increase of <D>[grey] was faster than <D>[white] from 4-7 to 10-14 days. FA[white] decreased more rapidly than FA[grey] during the first week, thereafter for both tissue types the FA decreased gradually. However, FA[white] was still higher than FA[grey] at three months indicating that some organised axonal structure remained. This effect was more marked in some patients than in others. <D>R[grey] was significantly higher than <D>R[white] within 24 hours and at 10-14 days (p<0.05), and FAR[white] was significantly more reduced than FAR[grey] at all time points (p<0.001). CONCLUSIONS: The values and temporal evolution of <D> and FA are different for grey and white matter after human ischaemic stroke. The observation that there is patient-to-patient variability in the degree of white matter structure remaining within the infarct at three months may have implications for predicting patient outcome. |
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Authors:
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S Muñoz Maniega; M E Bastin; P A Armitage; A J Farrall; T K Carpenter; P J Hand; V Cvoro; C S Rivers; J M Wardlaw |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 75 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-19 Completed Date: 2004-12-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 1714-8 Citation Subset: IM |
Affiliation:
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SHEFC Brain Imaging Research Centre for Scotland, UK. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Anisotropy Brain / pathology* Brain Ischemia / complications, pathology* Diffusion Magnetic Resonance Imaging Female Follow-Up Studies Humans Male Middle Aged Stroke / complications, pathology* Time Factors |
| Comments/Corrections | |
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