| Temporal evolution of skeletal regenerated tissue: what can mechanical investigation add to biological? | |
| | |
MedLine Citation:
|
PMID: 20517709 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The objective here was to experimentally characterize the temporal evolution of the structural and mechanical properties of large volume immature regenerated tissues. We studied these evolving tissues from their genesis in controlled mechanical conditions. We developed an animal model based on the periosteal properties leading to unloaded regenerated skeletal tissue. To characterize the temporal evolution of mechanical properties, we carried out indentation tests coupled with macroscopic examinations and histological studies. This combined methodology yielded a range of information on osteogenesis at different scales: macroscopic by simple observation, mesoscopic by indentation test and microscopic by histological study. Results allowed us to identify different periods, providing a link between biological changes and material property evolution in bone tissue regeneration. The regenerated tissue evolves from a viscous, homogeneous, soft material to a heterogeneous stiffer material endowed with a lower viscosity. From a biological point of view, cell organization progresses from a proliferated cell clot to a mature structure closer to that of the bone. During the first 7 days, mechanical and biological results revealed the same evolution: first, the regenerated tissue grew, then, differentiated into an osteochondral tissue and finally calcification began. While our biological results confirm those of other studies, our mechanical results provide the first experimental mechanical characterization by reduced Young's modulus of such tissue. |
| | |
Authors:
|
Remy Casanova; Didier Moukoko; Martine Pithioux; Cyril Pailler-Mattéi; Hassan Zahouani; Patrick Chabrand |
Related Documents
:
|
20369989 - Third- and fourth-order elasticities of biological soft tissues. 19058949 - An advanced hybrid cutting method with an improved state machine for surgical simulation. 18798289 - Evaluation of laser beam profile in soft tissue due to compression, glycerol, and micro... 19964349 - Numerical models of laser fusion of intestinal tissues. 10412379 - Identification and determination of material properties for porohyperelastic analysis o... 17361459 - Three-dimensional pore space quantification of apple tissue using x-ray computed microt... 18026499 - Self-optical parametric oscillation in periodically poled neodymium-doped lithium niobate. 22016249 - Noctilucent clouds: modern ground-based photographic observations by a digital camera n... 20389379 - Small volume excitation and enhancement of dye fluorescence on a 2d photonic crystal su... |
Publication Detail:
|
Type: Journal Article Date: 2010-06-02 |
Journal Detail:
|
Title: Medical & biological engineering & computing Volume: 48 ISSN: 1741-0444 ISO Abbreviation: Med Biol Eng Comput Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7704869 Medline TA: Med Biol Eng Comput Country: United States |
Other Details:
|
Languages: eng Pagination: 811-9 Citation Subset: IM |
Affiliation:
|
Institut des Sciences du Mouvement, Aix Marseille Université, CNRS-UMR 6233, 13009, Marseille, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phase-resetting curve determines how BK currents affect neuronal firing.
Next Document: Dynamics of magnetic particles in cylindrical Halbach array: implications for magnetic cell separati...