| Temporal dynamics of direction tuning in motion-sensitive macaque area MT. | |
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MedLine Citation:
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PMID: 15537817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the temporal dynamics of motion direction sensitivity in macaque area MT using a motion reverse correlation paradigm. Stimuli consisted of a random sequence of motion steps in eight different directions. Cross-correlating the stimulus with the resulting neural activity reveals the temporal dynamics of direction selectivity. The temporal dynamics of direction selectivity at the preferred speed showed two phases along the time axis: one phase corresponding to an increase in probability for the preferred direction at short latencies and a second phase corresponding to a decrease in probability for the preferred direction at longer latencies. The strength of this biphasic behavior varied between neurons from weak to very strong and was uniformly distributed. Strong biphasic behavior suggests optimal responses for motion steps in the antipreferred direction followed by a motion step in the preferred direction. Correlating spikes to combinations of motion directions corroborates this distinction. The optimal combination for weakly biphasic cells consists of successive steps in the preferred direction, whereas for strongly biphasic cells, it is a reversal of directions. Comparing reverse correlograms to combinations of stimuli to predictions based on correlograms for individual directions revealed several nonlinear effects. Correlations for successive presentations of preferred directions were smaller than predicted, which could be explained by a static nonlinearity (saturation). Correlations to pairs of (nearly) opposite directions were larger than predicted. These results show that MT neurons are generally more responsive when sudden changes in motion directions occur, irrespective of the preferred direction of the neurons. The latter nonlinearities cannot be explained by a simple static nonlinearity at the output of the neuron, but most likely reflect network interactions. |
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Authors:
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János A Perge; Bart G Borghuis; Roger J E Bours; Martin J M Lankheet; Richard J A van Wezel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-11-10 |
Journal Detail:
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Title: Journal of neurophysiology Volume: 93 ISSN: 0022-3077 ISO Abbreviation: J. Neurophysiol. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-03-18 Completed Date: 2005-04-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375404 Medline TA: J Neurophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 2104-16 Citation Subset: IM |
Affiliation:
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Functional Neurobiology, Helmholtz Institute, Faculty Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology* Animals Macaca mulatta Male Motion Perception / physiology* Photic Stimulation / methods* Temporal Lobe / physiology* Time Factors |
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