| Temporal diabetes and diuresis-induced alteration of nerves and vasculature of the urinary bladder in the rat. | |
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MedLine Citation:
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PMID: 21087392 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: • To characterize the temporal changes of the nerves and vasculature of the bladder in diabetic rats. MATERIALS AND METHODS: • A total of 36 Sprague-Dawley rats were divided into three groups: streptozotocin-induced diabetics, 5% sucrose-induced diuretics and age-matched controls. • The characteristics of the nerves and vasculature in the equatorial cross-sectional areas of the bladder were examined by immunofluorescence staining of their specific markers, neurofilament 200 (NF200) and CD31, at 1, 9 or 20 weeks after induction. • The distributions of the nerves and blood vessels were observed and the densities were quantified. RESULTS: • Diabetes caused a significant reduction in body weight. Bladder weight increased in diabetic and diuretic rats, but not in controls. • The total cross-sectional wall area and detrusor muscle area at the equatorial midline were greater in bladders of diabetic and diuretic rats than in controls. • Neurofilament 200-immunoreactive (NF200-IR) nerves were mainly distributed in the detrusor muscle. CD31-immunoreactive blood vessels were mainly distributed in the mucosa/submucosa. • There were no significant differences in the NF200-IR nerve terminal area among control, diabetic and diuretic groups. However nerve density was decreased at 9 and 20 weeks in the muscle, and at 20 weeks in the mucosa/submucosa in diabetic and diuretic animals. • Blood vessel density decreased in the diabetic and diuretic groups at 20 weeks in the muscle. CONCLUSIONS: • Diabetes induced time-dependent changes in the density of the nerves and vasculature in the bladder tissues. • Diabetes-related polyuria plays an important role in these changes. |
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Authors:
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Guiming Liu; Mei Li; Amit Vasanji; Firouz Daneshgari |
Publication Detail:
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Type: Journal Article Date: 2010-11-18 |
Journal Detail:
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Title: BJU international Volume: 107 ISSN: 1464-410X ISO Abbreviation: BJU Int. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100886721 Medline TA: BJU Int Country: England |
Other Details:
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Languages: eng Pagination: 1988-93 Citation Subset: IM |
Copyright Information:
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© 2010 THE AUTHORS. BJU INTERNATIONAL © 2010 BJU INTERNATIONAL. |
Affiliation:
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Department of Urology and Division of Infectious Disease, Case Western Reserve UniversityBiomedical Imaging & Analysis Core, The Cleveland Clinic, Cleveland, OH, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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